{"id":"W2119655850","doi":"10.1186/1756-8935-6-15","title":"Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells","year":2013,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Gene silencing; Heterochromatin protein 1; Biology; Chromatin; Retrotransposon; Endogenous retrovirus; Embryonic stem cell; RNA interference; Genetics; Polycomb-group proteins; Heterochromatin; Cell biology; Gene; Repressor; Molecular biology; Gene expression; RNA; Transposable element; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225675,0.0003596845,0.0001869089,0.000257498,0.0000894751,0.0003749806,0.0002233246,0.0002710378,0.0009270899],"category_scores_gemma":[0.00007155365,0.0001941894,0.0002266953,0.0001009293,0.0002227646,0.0001839112,0.0002997226,0.0004420449,0.0003799751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002470441,"about_ca_system_score_gemma":0.0001204884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003108919,"about_ca_topic_score_gemma":0.00065806,"domain_scores_codex":[0.9998385,0.00001615782,0.00001769376,0.000051811,0.00005192363,0.00002395807],"domain_scores_gemma":[0.9998984,0.00001395073,0.00003833808,0.00001230342,0.000008030452,0.00002894895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002213787,0.000002644705,0.0001648682,0.0000104255,0.000001477337,0.00001566228,0.000006260885,0.00001727821,0.9994221,0.000030559,0.000004581453,0.0003020526],"study_design_scores_gemma":[0.000006876968,0.00007810143,0.01137374,0.000004937984,0.00001410383,0.0002071329,0.00003509939,0.0006417997,0.9866077,0.00002610831,0.001000755,0.000003730256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954335,0.001350461,0.001664139,0.00002728856,0.00000789499,0.00001167414,0.0004706958,0.00008171049,0.0009525865],"genre_scores_gemma":[0.9937617,0.0004400756,0.001385875,0.00003664787,0.000003227519,0.00002349534,0.0008341801,0.00003704891,0.003477772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009270899,"threshold_uncertainty_score":0.003101408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009619234140589605,"score_gpt":0.1897419298526734,"score_spread":0.1801226957120838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}