{"id":"W2119655850","doi":"10.1186/1756-8935-6-15","title":"Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells","year":2013,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Gene silencing; Heterochromatin protein 1; Biology; Chromatin; Retrotransposon; Endogenous retrovirus; Embryonic stem cell; RNA interference; Genetics; Polycomb-group proteins; Heterochromatin; Cell biology; Gene; Repressor; Molecular biology; Gene expression; RNA; Transposable element; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001503998,0.0001336562,0.0002285457,0.00001931854,0.0000596248,0.00002009778,0.0002471129,0.00007306361,0.0002335132],"category_scores_gemma":[0.00001902867,0.00005608163,0.0000610873,0.000323165,0.0001026124,0.00003679132,0.00005919949,0.00009783031,0.00000648863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001737675,"about_ca_system_score_gemma":0.00001005564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001645989,"about_ca_topic_score_gemma":0.006787059,"domain_scores_codex":[0.9988177,0.0001179709,0.0004557037,0.0002168491,0.0001873366,0.000204398],"domain_scores_gemma":[0.9994493,0.0001914365,0.0001642401,0.0001058872,0.00004289327,0.00004623936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000003069749,0.0001034715,0.06012871,0.00002279982,0.000002479351,3.723028e-7,0.0007378029,0.0001445244,0.9362994,0.00005152033,0.00003151891,0.002474278],"study_design_scores_gemma":[0.0001785203,0.00007586534,0.5742932,0.00005296072,0.000003811886,3.065784e-7,0.0003313175,0.0002900334,0.4242787,0.0003377851,0.00007190208,0.00008561663],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981412,0.000879894,0.000002761185,0.0002511659,0.00004482541,0.0003368755,0.00006941066,0.00000789829,0.000266],"genre_scores_gemma":[0.9990972,0.0002052584,0.0005157528,0.0000130498,0.00004007779,0.00001777402,0.000008851181,0.00000182538,0.000100243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5141644,"threshold_uncertainty_score":0.3787338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009619234140589605,"score_gpt":0.1897419298526734,"score_spread":0.1801226957120838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}