{"id":"W2119686984","doi":"10.1093/molbev/msn286","title":"Inferring Selection on Amino Acid Preference in Protein Domains","year":2008,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Wellcome Trust","keywords":"Biology; Genetics; Allele; Allele frequency; Mutation; Amino acid; Population; Selection (genetic algorithm); Natural selection; Neutral mutation; Negative selection; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001549673,0.0003192861,0.0004522025,0.0009585781,0.0002914642,0.000706027,0.000464265,0.0006443925,0.000668856],"category_scores_gemma":[0.006480509,0.0003098436,0.0005003209,0.0007827806,0.0005564364,0.0008892412,0.000429695,0.0004628193,0.0001255442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006172439,"about_ca_system_score_gemma":0.0003277893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002623025,"about_ca_topic_score_gemma":0.003413926,"domain_scores_codex":[0.9993042,0.0003808365,0.00002666767,0.0001659616,0.00007706338,0.00004525991],"domain_scores_gemma":[0.9974079,0.001793245,0.0003656867,0.000235931,0.00008219527,0.0001151228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007088165,0.000191571,0.4475875,0.0002894979,0.0004794604,0.0004521738,0.0002915913,0.3698601,0.1147421,0.01555425,0.000346612,0.04949645],"study_design_scores_gemma":[0.0000390446,0.0001578581,0.1066519,0.0000140163,0.00008520638,0.0003476654,0.0001513201,0.8621128,0.009169741,0.02079388,0.0004390274,0.0000375672],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.955945,0.0001229583,0.04319588,0.00006548275,0.000003684741,0.000009055239,0.0001091668,0.00006297822,0.0004859668],"genre_scores_gemma":[0.9943592,0.00006398286,0.005377246,0.00002439907,0.000003666751,0.000006788286,0.00006719436,0.000009471653,0.00008809801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002623025,"threshold_uncertainty_score":0.008195579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382912232993005,"score_gpt":0.2392257318789297,"score_spread":0.2253966095489996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}