{"id":"W2119740343","doi":"10.1110/ps.072764907","title":"Structural and biochemical characterization of a novel Mn<sup>2+</sup>‐dependent phosphodiesterase encoded by the <i>yfcE</i> gene","year":2007,"lang":"en","type":"article","venue":"Protein Science","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institute on Aging","keywords":"Phosphodiester bond; Active site; Biochemistry; Phosphodiesterase; Escherichia coli; Phosphatase; Binding site; Biology; Ligand (biochemistry); Protein superfamily; Peptide sequence; Protein structure; Hydrolase; Stereochemistry; Archaea; Chemistry; Enzyme; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421403,0.0004516842,0.0003544879,0.0001352378,0.0001579263,0.0004718294,0.0004201566,0.0005376637,0.0003467909],"category_scores_gemma":[0.0002560999,0.0001439036,0.0003434458,0.0002858584,0.000247646,0.0002066661,0.0001810835,0.0006009197,0.0003412721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004422963,"about_ca_system_score_gemma":0.0003325276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002204832,"about_ca_topic_score_gemma":0.001311993,"domain_scores_codex":[0.9998873,0.00001341365,0.00001197106,0.00002574057,0.00003748948,0.00002404432],"domain_scores_gemma":[0.9998192,0.0000239641,0.00005616077,0.00001810909,0.00003091511,0.00005176566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001254125,0.00003986788,0.0007625539,0.00005184713,0.00000974979,0.0003077496,0.00002526374,0.0002100875,0.9962852,0.0001014913,0.0001258285,0.001954874],"study_design_scores_gemma":[0.00004391685,0.0002823292,0.02713172,0.00001781193,0.00003855115,0.002801428,0.0001249261,0.002671792,0.9538811,0.00008246638,0.01289826,0.00002562539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944919,0.001120664,0.002752812,0.0002021156,0.00003718073,0.00002177295,0.0008230568,0.00004875545,0.0005016068],"genre_scores_gemma":[0.9762933,0.001001909,0.01192254,0.0001413719,0.00003006361,0.00003096246,0.007687725,0.00006098972,0.002831269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002204832,"threshold_uncertainty_score":0.004383981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108113896384429,"score_gpt":0.2323964719315053,"score_spread":0.2215850822930623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}