{"id":"W2119751382","doi":"10.1371/journal.ppat.1004058","title":"Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Wellcome Trust; Wellcome","keywords":"NKG2D; Biology; MHC class I; Human cytomegalovirus; Cell biology; Natural killer cell; Cell; Immune system; Gene; Cytotoxic T cell; Major histocompatibility complex; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009546888,0.0004408188,0.0002787707,0.0002095591,0.0001421164,0.0002413531,0.0001752091,0.0002298004,0.001008984],"category_scores_gemma":[0.0001264611,0.0001039543,0.0002986604,0.0001714007,0.0001521371,0.000187899,0.0002248874,0.0002843715,0.0003229592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003137528,"about_ca_system_score_gemma":0.0001898225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000338317,"about_ca_topic_score_gemma":0.0005860916,"domain_scores_codex":[0.9999075,0.0000118086,0.00001105745,0.00001761499,0.00002908858,0.00002287742],"domain_scores_gemma":[0.999943,0.000009044276,0.00001439653,0.000008641377,0.000009494695,0.00001533202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001217222,0.00001861189,0.000569021,0.00003724039,0.000005019217,0.000119141,0.000009019896,0.00006120038,0.9964413,0.00007650346,0.00003461949,0.002506529],"study_design_scores_gemma":[0.000009148491,0.0001551647,0.004252235,0.000003229762,0.00001337425,0.0006031308,0.00001756593,0.0005137578,0.9916215,0.00003086853,0.002776597,0.0000035563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990936,0.003792291,0.003310993,0.00007584548,0.00002161145,0.00003854337,0.0005203838,0.0001001129,0.001204163],"genre_scores_gemma":[0.9902416,0.001114058,0.004168875,0.00006670018,0.000006150504,0.00003595279,0.001366654,0.00002418987,0.002975773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001008984,"threshold_uncertainty_score":0.003375411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02476812188084148,"score_gpt":0.2446252627033912,"score_spread":0.2198571408225497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}