{"id":"W2119751382","doi":"10.1371/journal.ppat.1004058","title":"Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Wellcome Trust; Wellcome","keywords":"NKG2D; Biology; MHC class I; Human cytomegalovirus; Cell biology; Natural killer cell; Cell; Immune system; Gene; Cytotoxic T cell; Major histocompatibility complex; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001752797,0.0002224902,0.000247797,0.0001882661,0.0006226893,0.00003034022,0.0001404931,0.0002184539,0.001191562],"category_scores_gemma":[0.0001126346,0.0002141504,0.0002005782,0.0001220234,0.00006307916,0.0001797151,0.00004287252,0.000255315,0.001718924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000789428,"about_ca_system_score_gemma":0.00002968579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003362072,"about_ca_topic_score_gemma":0.00001586179,"domain_scores_codex":[0.9986932,0.0001235617,0.0003702404,0.0003988864,0.00005057873,0.0003634866],"domain_scores_gemma":[0.9991047,0.0001474938,0.0001884878,0.0003421197,0.0001840969,0.00003314271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001569271,0.0004681482,0.0004437055,0.00002514062,0.00006866003,2.083111e-7,0.00008473465,0.00002565055,0.9893866,0.0005924634,0.008311498,0.0004362333],"study_design_scores_gemma":[0.00275598,0.0005179297,0.00116978,0.00002281366,0.0001458163,0.00002033017,0.0001715051,0.0004355581,0.7703252,0.00007351077,0.224069,0.000292566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9143216,0.0003342047,0.06302267,0.0002222698,0.005739148,0.0008737742,0.0001598035,0.0003668067,0.01495969],"genre_scores_gemma":[0.9660527,0.000009460321,0.001225733,0.0003158573,0.0002037934,0.0001272532,0.002099011,0.00004370127,0.02992249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2190614,"threshold_uncertainty_score":0.9997215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02476812188084148,"score_gpt":0.2446252627033912,"score_spread":0.2198571408225497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}