{"id":"W2119777544","doi":"10.1517/17460441.3.9.1041","title":"Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases","year":2008,"lang":"en","type":"article","venue":"Expert Opinion on Drug Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Pyrogenesis (Canada)","funders":"","keywords":"Vorinostat; Histone deacetylase; Histone; Medicine; Epigenetics; Bioinformatics; Cancer; Inflammation; Cancer research; Pharmacology; Computational biology; Biology; Immunology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003934286,0.0001546115,0.0001794612,0.00004414334,0.0001547946,0.000005923559,0.00007450382,0.00005138963,0.00000928702],"category_scores_gemma":[0.0000458743,0.0001056066,0.0001350816,0.00005311613,0.000457255,0.00001180733,0.0000358488,0.00003575949,3.658337e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004930388,"about_ca_system_score_gemma":0.0001219343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001133276,"about_ca_topic_score_gemma":0.00004896174,"domain_scores_codex":[0.9990958,0.00008553336,0.0002140299,0.0002869407,0.0001654687,0.000152217],"domain_scores_gemma":[0.9994872,0.0001195956,0.0001053815,0.0001805853,0.00005076757,0.00005642891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001750711,0.001335156,0.001526364,0.00003688121,0.0001631617,0.000001986946,0.0008847059,0.001010966,0.9648904,0.0001534242,0.02103397,0.007212249],"study_design_scores_gemma":[0.001440105,0.001058692,0.001818693,0.00002190065,0.000009060843,0.000001566979,0.0001417258,0.0001311147,0.949754,0.000006485301,0.04549042,0.000126212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650738,0.03329205,0.0001163422,0.0004024457,0.0002828529,0.0005555805,0.0002435548,0.000006269744,0.00002708162],"genre_scores_gemma":[0.913541,0.08522829,0.00002260686,0.00007498547,0.0002894268,0.0004134837,0.000115958,0.00001690897,0.0002973521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05193624,"threshold_uncertainty_score":0.4306511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02310778815169696,"score_gpt":0.353628319070424,"score_spread":0.3305205309187271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}