{"id":"W2119779956","doi":"10.1016/j.chembiol.2011.01.009","title":"Confronting the Challenges of Natural Product-Based Antifungal Discovery","year":2011,"lang":"en","type":"review","venue":"Chemistry & Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Merck Canada Inc. (Canada)","funders":"Merck","keywords":"Drug discovery; Antifungal; Natural product; Identification (biology); Biology; Biochemical engineering; Biotechnology; Computational biology; Antimicrobial; Pharmaceutical industry; Risk analysis (engineering); Nanotechnology; Business; Data science; Computer science; Bioinformatics; Engineering; Ecology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001037573,0.0008897065,0.001372191,0.001564947,0.0003921337,0.00152333,0.001271779,0.001445698,0.00290805],"category_scores_gemma":[0.0008804414,0.0003655611,0.0003827448,0.001950192,0.0009645416,0.002778485,0.001074919,0.003041852,0.002181152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008268629,"about_ca_system_score_gemma":0.001324289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008157464,"about_ca_topic_score_gemma":0.002809724,"domain_scores_codex":[0.9997954,0.00002897889,0.00001847683,0.00003236414,0.00009890966,0.00002590939],"domain_scores_gemma":[0.9994679,0.0002655596,0.0000558793,0.00001837096,0.000128108,0.00006420348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007787931,0.00008512445,0.0001065151,0.007969975,0.00006177451,0.0002385492,0.00004815939,0.0005555032,0.00531027,0.008094369,0.0384232,0.9390287],"study_design_scores_gemma":[0.00001873013,0.00005891021,0.0002446698,0.0008972876,0.00005006329,0.0006721223,0.00004239103,0.0001993873,0.001112352,0.003207082,0.9934803,0.00001673683],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001778611,0.9966509,0.0007305664,0.0006102775,0.0003544502,0.000004592864,0.00001319161,0.00001466598,0.001443528],"genre_scores_gemma":[0.0008511738,0.9964883,0.0008094989,0.0004050474,0.0003300263,0.000005740904,0.00003023394,0.000002349327,0.001077652],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00290805,"threshold_uncertainty_score":0.009728372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05025889578743649,"score_gpt":0.3017118273830163,"score_spread":0.2514529315955799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}