{"id":"W2119811461","doi":"10.1158/1055-9965.epi-10-0517","title":"Association of the Variants<i>CASP8</i>D302H and<i>CASP10</i>V410I with Breast and Ovarian Cancer Risk in<i>BRCA1</i>and<i>BRCA2</i>Mutation Carriers","year":2010,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Cancer Institute; Instituto de Salud Carlos III; National Institutes of Health; Deutsche Krebshilfe; Sahlgrenska Universitetssjukhuset; Cancer Care Ontario; Akademiska Sjukhuset; Cancerfonden; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Uppsala Universitet; Fox Chase Cancer Center; Lunds Universitet; National Breast Cancer Foundation; Ministerio de Ciencia e Innovación; National Institute for Health and Care Research; National Health and Medical Research Council; Cancer Research UK; Canadian Breast Cancer Research Alliance; Royal Marsden NHS Foundation Trust; Medical Research Council; Mayo Clinic; Breast Cancer Research Foundation; Deutsches Krebsforschungszentrum; Université Laval","keywords":"Breast cancer; Ovarian cancer; Oncology; Internal medicine; Allele; Hazard ratio; Medicine; Population; Cancer; Minor allele frequency; Case-control study; Bioinformatics; Allele frequency; Genetics; Biology; Confidence interval; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005358495,0.0003725519,0.0002892097,0.0005481641,0.0002219952,0.0002980184,0.0003333481,0.000543168,0.001852781],"category_scores_gemma":[0.001334849,0.0002456977,0.0006012494,0.0005536138,0.0002736115,0.0001409207,0.000253238,0.0003778936,0.0001569387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000167396,"about_ca_system_score_gemma":0.0001640282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003646008,"about_ca_topic_score_gemma":0.00260158,"domain_scores_codex":[0.9996817,0.00007613173,0.00002867235,0.0001330071,0.00003415248,0.00004619653],"domain_scores_gemma":[0.9990143,0.0002932476,0.0004100337,0.00009029593,0.00005412641,0.0001380731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001684132,0.00004568136,0.9923921,0.00001223423,0.0002726,0.0002286383,0.00006147615,0.0001266701,0.003598951,0.00002796416,0.0000677742,0.001481663],"study_design_scores_gemma":[0.00006340368,0.0002775957,0.9973889,0.000005443872,0.000217662,0.0007700599,0.00004338713,0.000448556,0.0005855573,0.00006550142,0.0001283712,0.000005493579],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995635,0.00009727502,0.0000931,0.00001159126,0.000002415618,0.000003839494,0.000149217,0.000002340029,0.00007672532],"genre_scores_gemma":[0.9994944,0.00003562359,0.0001349372,0.000008205936,0.000004922226,0.000005504768,0.0001887337,0.000002283734,0.0001253157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003646008,"threshold_uncertainty_score":0.007249594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008648803637466389,"score_gpt":0.2817510814130067,"score_spread":0.2731022777755403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}