{"id":"W2119813293","doi":"10.1006/dbio.2001.0486","title":"APH-2/Nicastrin Functions in LIN-12/Notch Signaling in the Caenorhabditis elegans Somatic Gonad","year":2001,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Center for Research Resources; National Institutes of Health","keywords":"Biology; Notch signaling pathway; Caenorhabditis elegans; Nicastrin; Presenilin; Cell biology; Somatic cell; Gonad; Hes3 signaling axis; Wnt signaling pathway; Zebrafish; Nodal signaling; Genetics; Embryo; Signal transduction; Anatomy; Embryogenesis; Internal medicine; Gene; Gastrulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003599247,0.0002116755,0.0002020484,0.0001182562,0.0001112373,0.00002917446,0.0003604158,0.0002296123,0.00008659834],"category_scores_gemma":[0.00006379256,0.0001815687,0.00005989668,0.0002102634,0.0001227606,0.00000619249,0.0001205349,0.0002143373,0.00006660251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005848335,"about_ca_system_score_gemma":0.0001337047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002636758,"about_ca_topic_score_gemma":0.003814303,"domain_scores_codex":[0.9984658,0.0001716863,0.0003983007,0.000416276,0.00009205037,0.0004558665],"domain_scores_gemma":[0.9995724,0.00004331156,0.00006979666,0.0002344094,0.00002578798,0.00005430184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005133154,0.0002621843,0.3213448,0.00001622086,0.00005130297,0.00005292687,0.001975419,0.0002235827,0.6699347,0.0001139867,0.0006166275,0.005356923],"study_design_scores_gemma":[0.005431781,0.001217784,0.5973525,0.0001097923,0.00006641933,0.00137843,0.01178469,0.0003133846,0.2204248,0.002392259,0.1573407,0.002187487],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958301,0.0003059397,0.001490467,0.0004851798,0.0002384458,0.0002665696,0.00001640409,0.00001288975,0.001354038],"genre_scores_gemma":[0.9963846,0.0001832609,0.001625247,0.0009158453,0.0001374643,0.00006259921,0.0003642006,0.00001938654,0.0003074297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4495099,"threshold_uncertainty_score":0.7404157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572778929656007,"score_gpt":0.2358306089666501,"score_spread":0.22010281967009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}