{"id":"W2119818163","doi":"10.1001/jama.295.2.165","title":"Comparison of β-Blockers, Amiodarone Plus β-Blockers, or Sotalol for Prevention of Shocks From Implantable Cardioverter Defibrillators<SUBTITLE>The OPTIC Study: A Randomized Trial</SUBTITLE>","year":2006,"lang":"en","type":"article","venue":"JAMA","topic":"Cardiac pacing and defibrillation studies","field":"Medicine","cited_by":781,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Sotalol; Medicine; Amiodarone; Beta blocker; Cardiology; Internal medicine; Antiarrhythmic agent; Randomized controlled trial; Anesthesia; Implantable cardioverter-defibrillator; Hazard ratio; Shock (circulatory); Atrial fibrillation; Confidence interval; Heart failure; Heart disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00201432,0.001441332,0.003293053,0.0005746604,0.0003675624,0.001140951,0.0009059207,0.002013952,0.004991973],"category_scores_gemma":[0.003669542,0.0007153276,0.002982296,0.000448013,0.001035941,0.0007932867,0.0004555163,0.001996899,0.0005243382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007782402,"about_ca_system_score_gemma":0.001161992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222092,"about_ca_topic_score_gemma":0.00293545,"domain_scores_codex":[0.9984458,0.000915478,0.0001835302,0.0001988557,0.00011033,0.0001459927],"domain_scores_gemma":[0.9975846,0.0009535703,0.0007681461,0.0001161209,0.0001003211,0.0004772963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9919209,0.001757542,0.0004823605,0.0005174274,0.00107136,0.00001221969,0.00001741786,0.00008698206,0.0006132625,0.00003153491,0.0001397483,0.00334939],"study_design_scores_gemma":[0.9641966,0.03301521,0.00102859,0.00004505482,0.001211674,0.00001191264,0.00001228111,0.0001297688,0.0001536995,0.00004876347,0.0001395746,0.000006869139],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892606,0.006196392,0.0003410109,0.0005381578,0.0006247794,0.001510233,0.000434463,0.00003593342,0.001058363],"genre_scores_gemma":[0.9885947,0.004467284,0.001055339,0.0008671224,0.00084088,0.002300319,0.0005511038,0.00001364417,0.001309752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004991973,"threshold_uncertainty_score":0.01669985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03139353282727531,"score_gpt":0.3253611856177263,"score_spread":0.293967652790451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}