{"id":"W2119847432","doi":"10.4049/jimmunol.169.10.5679","title":"Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Inflammatory Stimuli Up-Regulate Secretion of the Soluble GM-CSF Receptor in Human Monocytes: Evidence for Ectodomain Shedding of the Cell Surface GM-CSF Receptor α Subunit","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Cancer Foundation","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"Ectodomain; Secretion; Biology; Alternative splicing; Cell culture; Cell biology; Receptor; Molecular biology; Granulocyte macrophage colony-stimulating factor; Cytokine; Gene isoform; Gene; Immunology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241176,0.0002987734,0.0002492743,0.0002046464,0.000123786,0.0002671123,0.00007252819,0.0002592158,0.0007203133],"category_scores_gemma":[0.0001340135,0.0001571609,0.0003304828,0.0001916222,0.0001542863,0.0001026918,0.0001710784,0.0004058689,0.0004990562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001579732,"about_ca_system_score_gemma":0.0001895695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007951997,"about_ca_topic_score_gemma":0.001052544,"domain_scores_codex":[0.999843,0.00003375965,0.00002018397,0.0000156377,0.00003518606,0.00005222328],"domain_scores_gemma":[0.9999044,0.00002234324,0.00001713165,0.00001156048,0.00001379591,0.00003070793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002840852,0.00002927752,0.0004265631,0.00002274038,0.000004040015,0.0001299258,0.00001999034,0.00001221627,0.9984237,0.00001521339,0.00002072173,0.000611542],"study_design_scores_gemma":[0.00008077667,0.001138317,0.04432691,0.00001127606,0.00004641716,0.001452787,0.00009102419,0.0006343563,0.9499511,0.00006444636,0.002195533,0.000007118316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963456,0.001884739,0.0006347783,0.00008227633,0.00002333652,0.00002756885,0.0002539169,0.00002101618,0.000726947],"genre_scores_gemma":[0.9962637,0.001021291,0.00137036,0.00009775457,0.00001690273,0.00003683016,0.0004696831,0.000006570493,0.0007169664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007951997,"threshold_uncertainty_score":0.002409697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03534540862954449,"score_gpt":0.2707416338775859,"score_spread":0.2353962252480414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}