{"id":"W2119865335","doi":"10.1016/j.canlet.2008.05.006","title":"Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer","year":2008,"lang":"en","type":"article","venue":"Cancer Letters","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto; Jewish General Hospital; McGill University Health Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"CHEK2; Prostate cancer; Missense mutation; Genetics; Biology; Population; Cancer; Prostate; Cancer research; Mutation; Medicine; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006812129,0.00009140172,0.0001056684,0.00007398282,0.00002275055,0.000007351509,0.00007061119,0.00005109738,0.000006328283],"category_scores_gemma":[0.000005840788,0.00009190373,0.00001211449,0.000185121,0.0001082326,0.00001322919,0.00002192783,0.00005711633,2.948199e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001101419,"about_ca_system_score_gemma":0.0001394297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001583718,"about_ca_topic_score_gemma":0.0003951818,"domain_scores_codex":[0.9993134,0.0000168755,0.0001924509,0.000259743,0.0000869137,0.0001306091],"domain_scores_gemma":[0.9996647,0.000002937349,0.0001154437,0.0001457048,0.00004961236,0.00002159768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007698384,0.00002303491,0.1135687,0.00002763922,0.00001497662,0.000001363658,0.0005112456,0.0007957325,0.8831027,0.000001801262,0.0002367543,0.00163912],"study_design_scores_gemma":[0.001134656,0.0000230802,0.5497093,0.00005637716,0.000007930012,0.00000505383,0.00002918324,0.00031986,0.4470182,0.000001425285,0.00155683,0.000138039],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970391,0.0004590309,0.0004807787,0.00159087,0.00006582912,0.000260607,0.00005941679,0.000003738443,0.00004059359],"genre_scores_gemma":[0.9975729,0.001098392,0.000134011,0.0005584423,0.00006755139,0.0002859898,0.00008495431,0.00001714852,0.0001806277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4361407,"threshold_uncertainty_score":0.3747725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069997921382665,"score_gpt":0.247191305020734,"score_spread":0.2364913258069074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}