{"id":"W2119988496","doi":"10.2174/1875397301005010085","title":"Structural Chemistry of Human SET Domain Protein Methyltransferases","year":2011,"lang":"en","type":"article","venue":"Current Chemical Genomics","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"","keywords":"Methyltransferase; Methylation; Structural biology; Chemistry; Computational biology; Substrate (aquarium); Methionine; Biochemistry; Domain (mathematical analysis); Epigenetics; Biology; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255022,0.0002473684,0.0001732869,0.0001160853,0.0002052054,0.0002161727,0.0002833566,0.0003929178,0.003349927],"category_scores_gemma":[0.0001191897,0.0001289025,0.0001667598,0.0001604394,0.0002017372,0.0002132266,0.0002054331,0.0006143525,0.0008127142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005412336,"about_ca_system_score_gemma":0.0002063481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000437683,"about_ca_topic_score_gemma":0.0004717701,"domain_scores_codex":[0.9999341,0.00001296625,0.000002357179,0.000013754,0.0000246419,0.00001214203],"domain_scores_gemma":[0.9999752,0.000006994916,0.000004739609,0.000002547569,0.000004745072,0.000005657675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00032745,0.00006197536,0.0009937448,0.0004804476,0.00007177355,0.000456583,0.0001272062,0.005037759,0.928215,0.02387935,0.002408271,0.03794034],"study_design_scores_gemma":[0.00006444594,0.0005997249,0.002984265,0.00003539331,0.00004583004,0.002114745,0.0000823987,0.003653241,0.9030727,0.008742227,0.07857108,0.00003391693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7907327,0.0861202,0.05408466,0.003568997,0.0003841953,0.0001115136,0.001378848,0.0006192852,0.06299949],"genre_scores_gemma":[0.9654821,0.01487438,0.007792761,0.000476803,0.00005623116,0.00002632738,0.000911887,0.00003225021,0.01034723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003349927,"threshold_uncertainty_score":0.01120663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02940522185338277,"score_gpt":0.2709217549970711,"score_spread":0.2415165331436883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}