{"id":"W2119999174","doi":"10.1093/carcin/bgg195","title":"Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma","year":2003,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Protein kinase B; Wortmannin; Signal transduction; Cancer research; Cell biology; Biology; P70-S6 Kinase 1; Kinase; Phosphoinositide 3-kinase; PI3K/AKT/mTOR pathway; Cyclin-dependent kinase 4; Phosphorylation; Chemistry; MAP kinase kinase kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003613545,0.0001503502,0.0002048591,0.00005621318,0.00004182379,0.000004375657,0.0002663275,0.0001417953,0.00002224818],"category_scores_gemma":[0.00009947186,0.0001189202,0.0001357384,0.000236127,0.0001217519,0.000002574546,0.00009651396,0.00006569169,7.117808e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004537226,"about_ca_system_score_gemma":0.0002330308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003806555,"about_ca_topic_score_gemma":0.00003451894,"domain_scores_codex":[0.9987046,0.0001888902,0.0003526703,0.000297768,0.0002333819,0.0002227129],"domain_scores_gemma":[0.9991074,0.00002091881,0.0002098751,0.0004845404,0.0001299876,0.00004732367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004765056,0.00006928706,0.2582895,0.00007054344,0.000018143,0.00000226065,0.0000890827,0.000224782,0.7403767,0.00006738086,0.00005014372,0.0006945463],"study_design_scores_gemma":[0.0005338738,0.000244472,0.02068309,0.0001020288,0.00001885075,0.000002148585,0.0001256032,0.00001294687,0.9772579,0.00004403001,0.0008487532,0.0001263165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912828,0.007878576,0.00008993433,0.00001949519,0.0001829855,0.0003090561,0.00002019506,0.000003849294,0.000213108],"genre_scores_gemma":[0.9993245,0.00003315065,0.0003913155,0.00006718729,0.00004584721,0.00005255742,0.00001054572,0.00002337642,0.00005150956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2376065,"threshold_uncertainty_score":0.4849426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01858382915537531,"score_gpt":0.2543614970579193,"score_spread":0.235777667902544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}