{"id":"W2120063386","doi":"10.1093/nar/gkl830","title":"NHEJ-deficient DT40 cells have increased levels of immunoglobulin gene conversion: evidence for a double strand break intermediate","year":2006,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Biology; Cytidine deaminase; Gene conversion; Activation-induced (cytidine) deaminase; Ku70; Molecular biology; Homologous recombination; DNA; Immunoglobulin gene; Non-homologous end joining; DNA repair; Antibody; Gene; Immunoglobulin class switching; Genetics; Recombination; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008231595,0.0003518504,0.0002236653,0.0002480756,0.0001082805,0.000308779,0.0001490059,0.0003494119,0.002183788],"category_scores_gemma":[0.00009051651,0.0001405605,0.0001470026,0.0001448901,0.0001851767,0.0001779152,0.0001572654,0.0006071317,0.0004625503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002069218,"about_ca_system_score_gemma":0.00009144097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006490515,"about_ca_topic_score_gemma":0.0006605459,"domain_scores_codex":[0.9998542,0.0000148672,0.00001707336,0.0000333287,0.00004252934,0.00003797581],"domain_scores_gemma":[0.9998006,0.00002828184,0.00004943559,0.00003273981,0.00001873687,0.00007020742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000182356,0.000004156316,0.00008219275,0.000005757386,9.253623e-7,0.00001508971,0.000003940488,0.000003370854,0.9997514,0.00001467117,0.000002461284,0.00009783725],"study_design_scores_gemma":[0.000005753419,0.0001039545,0.00711856,0.000002155015,0.000006161472,0.000313694,0.00002018576,0.000130713,0.9916632,0.00002764759,0.0006062276,0.000001685348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996528,0.0006735232,0.001333357,0.00004025491,0.00001237837,0.00001306524,0.0004268824,0.00005451187,0.0009181504],"genre_scores_gemma":[0.9929699,0.0003703455,0.001849592,0.00003386619,0.00000564619,0.00001549867,0.001047924,0.00002429342,0.003682859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002183788,"threshold_uncertainty_score":0.007305503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08291895918349779,"score_gpt":0.3438729168013845,"score_spread":0.2609539576178868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}