{"id":"W2120070286","doi":"10.1158/1535-7163.mct-13-0598","title":"Pharmacodynamic and Antineoplastic Activity of BI 836845, a Fully Human IGF Ligand-Neutralizing Antibody, and Mechanistic Rationale for Combination with Rapamycin","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Università di Catania","keywords":"Pharmacology; In vitro; Signal transduction; Cancer; In vivo; Receptor; Monoclonal antibody; Cancer cell; Growth inhibition; Antibody; Cancer research; Biology; Medicine; Immunology; Cell biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003023291,0.0006511605,0.0005257946,0.000446145,0.0001607889,0.0004183061,0.0004359623,0.0003386082,0.0007728291],"category_scores_gemma":[0.0001681906,0.0002131573,0.000311868,0.0002308159,0.0002314113,0.0003072353,0.0001509927,0.000819811,0.0002738621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003594687,"about_ca_system_score_gemma":0.0003809851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004856905,"about_ca_topic_score_gemma":0.001039388,"domain_scores_codex":[0.9998109,0.00004947128,0.00002011549,0.00002668745,0.00004188615,0.00005103427],"domain_scores_gemma":[0.99993,0.000007923652,0.0000214017,0.000005689075,0.00001172195,0.00002321272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002231384,0.00139725,0.0007359678,0.0002469036,0.00006028539,0.0002319419,0.00003740821,0.002178804,0.9403977,0.000901596,0.0005941914,0.05098653],"study_design_scores_gemma":[0.0009827428,0.03389262,0.01017974,0.00004974391,0.0002930113,0.002561637,0.00004910149,0.007521017,0.918128,0.0003676834,0.02590008,0.0000745995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964079,0.01681334,0.009803821,0.0007088447,0.0001204245,0.0005351702,0.0005610375,0.0002816294,0.007096845],"genre_scores_gemma":[0.9842584,0.006107495,0.007133949,0.0002287734,0.00004674559,0.0001799501,0.0004313029,0.00002101537,0.001592471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007728291,"threshold_uncertainty_score":0.00260818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132143641633652,"score_gpt":0.3013254112828246,"score_spread":0.280003974866488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}