{"id":"W2120070286","doi":"10.1158/1535-7163.mct-13-0598","title":"Pharmacodynamic and Antineoplastic Activity of BI 836845, a Fully Human IGF Ligand-Neutralizing Antibody, and Mechanistic Rationale for Combination with Rapamycin","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Università di Catania","keywords":"Pharmacology; In vitro; Signal transduction; Cancer; In vivo; Receptor; Monoclonal antibody; Cancer cell; Growth inhibition; Antibody; Cancer research; Biology; Medicine; Immunology; Cell biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008418628,0.0001981509,0.0003150913,0.0001276496,0.0001106701,0.00003176092,0.00004862256,0.00007908943,0.00001249732],"category_scores_gemma":[0.000008502447,0.0001666926,0.00004676106,0.0001547835,0.0001074064,0.0001179,0.00002090395,0.0001236018,5.035333e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003425726,"about_ca_system_score_gemma":0.00008667642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001343864,"about_ca_topic_score_gemma":0.00001650889,"domain_scores_codex":[0.9990875,0.00003136922,0.0002100807,0.0002572995,0.0001993687,0.0002144471],"domain_scores_gemma":[0.9993554,0.00006385943,0.0001392543,0.0001309698,0.0002233415,0.0000872254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002025724,0.0001314427,0.005265985,0.000325148,0.0002313993,0.000004253001,0.0002616249,0.0000106809,0.9899353,0.001148187,0.000008609345,0.002474782],"study_design_scores_gemma":[0.00731498,0.00175835,0.06617742,0.000236794,0.0009148997,0.00004130668,0.0001145483,0.01777432,0.903704,0.001354299,0.0002376803,0.0003714446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809019,0.0009860827,0.01633373,0.0005760331,0.00005276085,0.001044044,0.00002247706,0.00002857171,0.00005441737],"genre_scores_gemma":[0.9985473,0.0003064626,0.0004795782,0.0004138849,0.00002519068,0.00009770099,0.0000418126,0.00003934464,0.0000487757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08623136,"threshold_uncertainty_score":0.6797528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132143641633652,"score_gpt":0.3013254112828246,"score_spread":0.280003974866488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}