{"id":"W2120088072","doi":"10.1074/mcp.m110.003616","title":"The Protein Interaction Network of the Human Transcription Machinery Reveals a Role for the Conserved GTPase RPAP4/GPN1 and Microtubule Assembly in Nuclear Import and Biogenesis of RNA Polymerase II","year":2010,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cell biology; Biogenesis; RNA polymerase II; Microtubule; Nuclear transport; Transcription (linguistics); GTPase; Polymerase; Biology; Chemistry; Computational biology; Cell nucleus; Genetics; Gene; Gene expression; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008372382,0.0001525478,0.0001720822,0.00002652495,0.0003612241,0.00004009622,0.0002545063,0.0001413496,0.000001711835],"category_scores_gemma":[0.0001065155,0.0000963038,0.0001284032,0.00009685729,0.0002263082,0.000007737598,0.0001515853,0.0002175876,8.179109e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008589862,"about_ca_system_score_gemma":0.0000555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005472936,"about_ca_topic_score_gemma":0.0003872123,"domain_scores_codex":[0.9988642,0.0001602843,0.0003416018,0.0002536613,0.0001266772,0.0002535383],"domain_scores_gemma":[0.9992045,0.00002404035,0.0001990984,0.0004413059,0.00007740147,0.0000536373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002410727,0.00004611936,0.001105787,0.00005192939,0.00004992783,0.000001513839,0.00005113071,0.00002223503,0.9971503,0.0002367333,0.00002455732,0.001018699],"study_design_scores_gemma":[0.000632556,0.0002091117,0.00144291,0.00003723522,0.00002972343,0.000009703435,0.00008190791,0.00130012,0.9954473,0.0002371673,0.0004667938,0.0001054225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955063,0.001550236,0.0004570309,0.0006226377,0.00004496274,0.001781568,0.00002092063,0.000003472698,0.00001288683],"genre_scores_gemma":[0.99886,0.00009176512,0.0006212381,0.000081197,0.0000482248,0.0001458518,0.00001878082,0.0000308395,0.0001020896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003353728,"threshold_uncertainty_score":0.3927155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006424840460117964,"score_gpt":0.2319152169650877,"score_spread":0.2254903765049698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}