{"id":"W2120088072","doi":"10.1074/mcp.m110.003616","title":"The Protein Interaction Network of the Human Transcription Machinery Reveals a Role for the Conserved GTPase RPAP4/GPN1 and Microtubule Assembly in Nuclear Import and Biogenesis of RNA Polymerase II","year":2010,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cell biology; Biogenesis; RNA polymerase II; Microtubule; Nuclear transport; Transcription (linguistics); GTPase; Polymerase; Biology; Chemistry; Computational biology; Cell nucleus; Genetics; Gene; Gene expression; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005407907,0.0001979104,0.0001272372,0.0003828169,0.0002095584,0.0002201487,0.0001657735,0.0001877215,0.001019037],"category_scores_gemma":[0.0001517109,0.0001624014,0.0001275598,0.0002574702,0.0001415151,0.0001814032,0.0001399281,0.000187264,0.000369634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004330625,"about_ca_system_score_gemma":0.0001493375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029521,"about_ca_topic_score_gemma":0.000949526,"domain_scores_codex":[0.999945,0.000008153388,0.000002206357,0.00002069999,0.00001547312,0.000008335444],"domain_scores_gemma":[0.9999592,0.000009829658,0.0000119931,0.000004461203,0.000005730369,0.000008661946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001981513,0.00001987891,0.004672535,0.00007470864,0.00002973844,0.0003944716,0.00003897777,0.001325378,0.9855281,0.0005807712,0.0003369546,0.006800411],"study_design_scores_gemma":[0.0000516473,0.000165315,0.2405933,0.00002388387,0.0002038571,0.003242437,0.0001479948,0.1034657,0.6281345,0.003458941,0.02048216,0.00003019547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952378,0.0009787055,0.002204616,0.00013829,0.000005304409,0.000005879632,0.0002360192,0.00006314355,0.001130174],"genre_scores_gemma":[0.9948745,0.0004217703,0.002381318,0.00003409518,0.000009599753,0.00001243658,0.0008543328,0.000008530114,0.001403429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029521,"threshold_uncertainty_score":0.003408968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006424840460117964,"score_gpt":0.2319152169650877,"score_spread":0.2254903765049698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}