{"id":"W2120090245","doi":"10.1152/ajpheart.00215.2014","title":"Repeated daily dosing with sildenafil provides sustained protection from endothelial dysfunction caused by ischemia and reperfusion: a human in vivo study","year":2014,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Sildenafil; Placebo; Anesthesia; Adverse effect; Ischemia; Pharmacology; Cardiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003743919,0.0002785133,0.0009816907,0.0001788158,0.00018883,0.00001425204,0.0000580997,0.0001362675,0.00002913206],"category_scores_gemma":[0.00007067311,0.0002002668,0.0001094935,0.000221644,0.0005506888,0.000130044,0.0000545266,0.0005486352,8.649726e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008067291,"about_ca_system_score_gemma":0.0001027632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003980033,"about_ca_topic_score_gemma":0.00001495127,"domain_scores_codex":[0.9980232,0.0003994639,0.0005182477,0.0005609471,0.0002029727,0.0002951877],"domain_scores_gemma":[0.9987852,0.00008833584,0.0004694224,0.0003086294,0.0001846036,0.0001638135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001751138,0.0002792689,0.02140216,0.0000411207,0.0001402403,0.000003534474,0.0008162633,0.0000122708,0.9747986,0.000002176061,0.0001329171,0.000620359],"study_design_scores_gemma":[0.008778194,0.009235376,0.8196636,0.0002370939,0.0003349079,0.0002809348,0.005182417,0.0002085139,0.1550285,0.0001127744,0.0005637945,0.0003738988],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990147,0.0001461585,0.000005852795,0.0001752776,0.0001057885,0.0004913451,0.000003603506,0.00002867539,0.00002860879],"genre_scores_gemma":[0.9991683,0.0000231157,0.00005474938,0.0002308254,0.0004287797,0.00002166953,0.00001158099,0.00003167934,0.00002934357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.81977,"threshold_uncertainty_score":0.8166642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006644584525706081,"score_gpt":0.2290660519378406,"score_spread":0.2224214674121345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}