{"id":"W2120098038","doi":"10.1161/circulationaha.109.848911","title":"Dehydroepiandrosterone Reverses Systemic Vascular Remodeling Through the Inhibition of the Akt/GSK3-β/NFAT Axis","year":2009,"lang":"en","type":"article","venue":"Circulation","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Protein kinase B; Medicine; Vascular smooth muscle; Endocrinology; GSK-3; Internal medicine; PI3K/AKT/mTOR pathway; Dehydroepiandrosterone; Cell biology; Signal transduction; Biology; Androgen; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002281674,0.00009605162,0.0001979345,0.0000234551,0.0001943438,0.000006372564,0.00004516426,0.00005122156,0.000004783886],"category_scores_gemma":[0.0001244297,0.00004986675,0.0001378494,0.0002135359,0.00008577985,0.00009982265,0.00002155518,0.0001094774,0.000007139841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006613268,"about_ca_system_score_gemma":0.00002372208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003747799,"about_ca_topic_score_gemma":0.000002843892,"domain_scores_codex":[0.9990723,0.00006945294,0.0002561077,0.0001998928,0.00029088,0.0001113323],"domain_scores_gemma":[0.9993088,0.00002245177,0.0001237502,0.000358176,0.0001712616,0.00001555535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001773394,0.0002371957,0.04418061,0.0004907605,0.0003388892,0.000006964266,0.0132614,0.01501413,0.9063907,0.003541708,0.0004537988,0.01590654],"study_design_scores_gemma":[0.00151462,0.0001519469,0.9515613,0.001374909,0.0005599332,0.0001839523,0.002565717,0.002506247,0.03009907,0.00830031,0.0009452666,0.0002367344],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906424,0.002893949,0.001928634,0.002469547,0.0001493907,0.0005168749,0.000001854259,0.00002618836,0.001371161],"genre_scores_gemma":[0.9992819,0.0001304542,0.00007182801,0.0002026979,0.0002322555,0.000005712202,0.000008328715,0.000007206168,0.00005954493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9073807,"threshold_uncertainty_score":0.2033507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02678373975565836,"score_gpt":0.2580595533680887,"score_spread":0.2312758136124303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}