{"id":"W2120109964","doi":"10.1186/1745-6215-13-199","title":"Rationale and design of the RIACT–study: a multi-center placebo controlled double blind study to test the efficacy of RItuximab in Acute Cellular tubulointerstitial rejection with B-cell infiltrates in renal Transplant patients: study protocol for a randomized controlled trial","year":2012,"lang":"en","type":"article","venue":"Trials","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"Universitätsklinikum Köln; Bundesministerium für Bildung und Forschung","keywords":"Medicine; Rituximab; Placebo; CD20; Internal medicine; T cell; B cell; Kidney; Renal function; Single Center; Clinical trial; Acute kidney injury; Immunology; Gastroenterology; Urology; Immune system; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04302772,0.009545739,0.01431671,0.002579703,0.003679575,0.005464994,0.004836926,0.008748377,0.02791649],"category_scores_gemma":[0.02770503,0.004700816,0.005594303,0.002910945,0.008412146,0.004259881,0.002079388,0.01020287,0.01014417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003271031,"about_ca_system_score_gemma":0.01151373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047366,"about_ca_topic_score_gemma":0.001817228,"domain_scores_codex":[0.9719341,0.01662484,0.002575804,0.003655241,0.003002251,0.002207747],"domain_scores_gemma":[0.9885639,0.002672745,0.002613307,0.001576079,0.002107487,0.002466465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9403017,0.008686122,0.001201944,0.01723829,0.002276165,0.0002811144,0.000255656,0.001447952,0.003900816,0.004377427,0.005272843,0.01475993],"study_design_scores_gemma":[0.9424395,0.02991697,0.001526851,0.002304688,0.001537095,0.00009990691,0.00007756828,0.001068382,0.0008607313,0.002298003,0.0177463,0.0001239495],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.007257663,0.002073703,0.003015379,0.0007212699,0.00116469,0.9829981,0.001236775,0.0002004528,0.00133197],"genre_scores_gemma":[0.009036197,0.0006981853,0.005698805,0.0008556119,0.0003199961,0.9823201,0.0003846158,0.00001994437,0.0006665867],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04302772,"threshold_uncertainty_score":0.227555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0845236552135892,"score_gpt":0.3812459284497503,"score_spread":0.2967222732361611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}