{"id":"W2120110014","doi":"10.1177/1756287212466128","title":"An evidence-based guide to the selection of sequential therapies in metastatic renal cell carcinoma","year":2012,"lang":"en","type":"article","venue":"Therapeutic Advances in Urology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Temsirolimus; Medicine; Sorafenib; Sunitinib; Axitinib; Everolimus; Pazopanib; Renal cell carcinoma; Oncology; Bevacizumab; Internal medicine; Context (archaeology); Targeted therapy; Cancer; Hepatocellular carcinoma; Chemotherapy; PI3K/AKT/mTOR pathway; Discovery and development of mTOR inhibitors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000729161,0.0001912899,0.0003731456,0.0002552686,0.00003347498,0.000004460991,0.0001704072,0.00006162214,0.0001372631],"category_scores_gemma":[0.00003086526,0.0001265671,0.00006721843,0.000419218,0.0001319695,0.0002415406,0.00001896018,0.0002051983,0.00001312518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000165855,"about_ca_system_score_gemma":0.0001302757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001705646,"about_ca_topic_score_gemma":0.0003105791,"domain_scores_codex":[0.998069,0.0005840481,0.0004246404,0.0002551652,0.0002337542,0.000433344],"domain_scores_gemma":[0.9989967,0.0003616419,0.0001290205,0.0003605739,0.00006304781,0.00008905964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005756265,0.001387292,0.693985,0.0001559328,0.00008278579,0.00005131375,0.004127628,0.01399118,0.2273342,0.0005164376,0.0000229746,0.05258896],"study_design_scores_gemma":[0.005218645,0.009242843,0.6979961,0.00008978654,0.0004878932,0.0001662818,0.0007707735,0.003677975,0.264822,0.0007731377,0.01634349,0.0004110677],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628604,0.03027395,0.004535165,0.001148164,0.0001646051,0.0007025966,0.000001994255,0.00001780959,0.0002952947],"genre_scores_gemma":[0.9955336,0.0002179538,0.00251084,0.00143127,0.000110166,0.0001253245,0.000005314739,0.0000233436,0.00004212496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05217789,"threshold_uncertainty_score":0.5161255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04916816897671784,"score_gpt":0.3490368308018426,"score_spread":0.2998686618251247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}