{"id":"W2120140702","doi":"10.1091/mbc.e13-11-0633","title":"Cytoskeletal confinement of CX<sub>3</sub>CL1 limits its susceptibility to proteolytic cleavage by ADAM10","year":2014,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Western University; Hospital for Sick Children; University of Toronto","funders":"Fondation Bettencourt Schueller; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Cytoskeleton; Biology; Cell biology; CX3CL1; Transmembrane protein; Actin cytoskeleton; ADAM10; CXCL16; Chemokine; Metalloproteinase; Disintegrin; Cell; Chemokine receptor; Biochemistry; Receptor; Matrix metalloproteinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175487,0.0001823944,0.0002161692,0.0001147715,0.0002554103,0.0005909148,0.0001994652,0.0002519406,0.001153015],"category_scores_gemma":[0.0002298521,0.0001637258,0.0001454667,0.00007802371,0.00031292,0.0003737698,0.0002532107,0.0003392209,0.0002816262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006634538,"about_ca_system_score_gemma":0.0003873814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001750787,"about_ca_topic_score_gemma":0.002501836,"domain_scores_codex":[0.9998463,0.00001935054,0.000008861014,0.00003574846,0.000029929,0.00005978615],"domain_scores_gemma":[0.9998356,0.00003708197,0.00004992024,0.00002011717,0.00002534761,0.00003183073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004769694,0.000007780662,0.0001981865,0.00001869309,0.000001780694,0.00002204501,0.00001521411,0.00006646707,0.9986784,0.0001694288,0.0000391866,0.0007350068],"study_design_scores_gemma":[0.00001180494,0.0001170099,0.007461052,0.00001141528,0.00001077137,0.0001441717,0.00006187859,0.002630208,0.9862275,0.0001188183,0.003199569,0.00000584359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948218,0.000923809,0.002750568,0.0001044138,0.00001365982,0.00001148204,0.00007609151,0.00004482934,0.001253372],"genre_scores_gemma":[0.9971227,0.000417671,0.001162855,0.00003892326,0.000005766091,0.00002021709,0.0001114129,0.00001603207,0.001104348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001750787,"threshold_uncertainty_score":0.004813731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006834158349032784,"score_gpt":0.2381498850869119,"score_spread":0.2313157267378791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}