{"id":"W2120140934","doi":"10.1073/pnas.0303859101","title":"Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis","year":2004,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; York University; Multiple Sclerosis Society; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Multiple Sclerosis Society","keywords":"Fibrin; Inflammation; Multiple sclerosis; Genetically modified mouse; Immunology; Tumor necrosis factor alpha; Medicine; Pathology; Transgene; Necrosis; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002089891,0.0007254999,0.0005735792,0.0006564704,0.0002424558,0.0003734699,0.0002326025,0.0006127481,0.001341633],"category_scores_gemma":[0.0001954834,0.0002934492,0.0002453316,0.0002811717,0.0004300825,0.0003158393,0.0002007829,0.0008751812,0.0005137897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003440349,"about_ca_system_score_gemma":0.0002543581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005889822,"about_ca_topic_score_gemma":0.001155707,"domain_scores_codex":[0.9997959,0.00003582768,0.00002992727,0.00004006781,0.00005219672,0.00004617366],"domain_scores_gemma":[0.9996634,0.0000275474,0.0001423937,0.00002660489,0.00002335094,0.0001167856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003891225,0.0000899416,0.0001206634,0.00004449037,0.000008738343,0.00008811487,0.00001372933,0.00005814536,0.9978015,0.00007415298,0.00006954949,0.001241951],"study_design_scores_gemma":[0.0002141781,0.002252684,0.004210684,0.00002793147,0.00006052054,0.0008943123,0.00003618488,0.0008618149,0.9883294,0.0002314725,0.002866086,0.00001472302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994331,0.001882497,0.001720958,0.0002578478,0.00003968013,0.00003291314,0.0003990518,0.0002752241,0.001060892],"genre_scores_gemma":[0.986691,0.002487801,0.004522342,0.0001409145,0.00003252771,0.00009485854,0.0008342832,0.00008543723,0.005110741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001341633,"threshold_uncertainty_score":0.00448823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231958241037655,"score_gpt":0.3342822911219043,"score_spread":0.2110864670181388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}