{"id":"W2120160057","doi":"10.1093/eurheartj/ehs042","title":"Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response","year":2012,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Paraoxonase enzyme and polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Clopidogrel; CYP2C19; PON1; Medicine; Pharmacology; Ticlopidine; Metabolite; Active metabolite; Platelet aggregation inhibitor; Antiplatelet drug; Pharmacokinetics; Internal medicine; Cytochrome P450; Platelet; Genotype; Chemistry; Biochemistry; Metabolism; Aspirin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002154041,0.00006182215,0.00008333827,0.00004711261,0.00004592451,0.000009909659,0.00007468711,0.00003403536,0.000004537686],"category_scores_gemma":[0.00008416614,0.00003844364,0.00002356299,0.00007034976,0.00005673525,0.00000988514,0.00003863953,0.0001623761,4.053725e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002832171,"about_ca_system_score_gemma":0.0000168507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003828379,"about_ca_topic_score_gemma":0.000005209159,"domain_scores_codex":[0.9989771,0.0005607131,0.0001910202,0.00006944332,0.00007683363,0.0001248408],"domain_scores_gemma":[0.9996799,0.0000572659,0.0001046359,0.0001158196,0.0000137439,0.0000286556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002573051,0.00002611318,0.1481658,0.000004707247,0.000007585391,0.000007658192,0.0005338032,0.000002128707,0.850338,0.0001327324,0.0003790175,0.0001451983],"study_design_scores_gemma":[0.0005808845,0.0001589484,0.7221297,0.00004034362,0.00000626727,0.0005552707,0.0003138086,0.00001241587,0.2679034,0.00005380554,0.008167028,0.00007809736],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996973,0.002132011,0.00005764766,0.000484453,0.00004698519,0.00005934564,0.000003802171,6.830277e-7,0.0002420232],"genre_scores_gemma":[0.9990299,0.000377214,0.0001165837,0.0003367279,0.0001074844,5.080434e-7,0.000001042377,0.000007345409,0.00002319905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5824345,"threshold_uncertainty_score":0.1567686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03058993984011732,"score_gpt":0.2849669765037564,"score_spread":0.2543770366636391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}