{"id":"W2120187999","doi":"10.1038/msb.2010.11","title":"Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity","year":2010,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; Eidgenössische Technische Hochschule Zürich; Austrian Science Fund","keywords":"Metabolite; Enzyme; Biology; Biochemistry; Metabolic pathway; Enzyme kinetics; Metabolomics; Saccharomyces cerevisiae; Metabolome; Enzyme assay; Bioinformatics; Active site; Yeast","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006230592,0.0003006484,0.0004583545,0.0002418254,0.00008873483,0.00003925107,0.0002254398,0.0004534819,0.000005229778],"category_scores_gemma":[0.0002373721,0.0002741884,0.0001069667,0.0002974157,0.0001454505,0.000007672539,0.00008628541,0.000337589,0.000006575014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001104993,"about_ca_system_score_gemma":0.00004666383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004034809,"about_ca_topic_score_gemma":0.00009066075,"domain_scores_codex":[0.9980759,0.0002499719,0.000428462,0.0006753964,0.00009287768,0.0004773719],"domain_scores_gemma":[0.9991455,0.00001191263,0.0001130997,0.0005120623,0.00007717968,0.0001402192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009070126,0.00004024055,0.002026889,0.00002637782,0.00006424226,0.000002440932,0.00007281909,0.0001010043,0.9911225,0.00486449,0.00002563706,0.001644218],"study_design_scores_gemma":[0.0007970117,0.0001637168,0.01582061,0.00001411439,0.00009445888,0.0001454182,0.00005818964,0.000273128,0.8352156,0.00008887488,0.1467574,0.0005714202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770173,0.009473098,0.01176829,0.0002058949,0.0008875059,0.0003891157,0.0001264103,0.00003843068,0.00009395101],"genre_scores_gemma":[0.9980309,0.0002975087,0.0006211023,0.00006219334,0.0005996505,0.0000573008,0.0002178214,0.00003369362,0.00007985122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1559069,"threshold_uncertainty_score":0.999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009101535682525662,"score_gpt":0.2266144460694126,"score_spread":0.2175129103868869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}