{"id":"W2120191503","doi":"10.4161/cbt.213","title":"Human Tumor Xenografts as Predictive Preclinical Models for Anticancer Drug Activity in Humans: Better than Commonly Perceived—But They Can Be Improved","year":2003,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Cancer Institute; St. Jude Children's Research Hospital","keywords":"Medicine; In vivo; Cancer; Drug; Transplantation; Cancer research; Efficacy; Pharmacology; Oncology; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002996095,0.0003534899,0.0004394359,0.00007676909,0.0002107094,0.00002885314,0.000338726,0.0002405008,0.00005939529],"category_scores_gemma":[0.00002760388,0.0002949284,0.0002285378,0.00007855953,0.0003612382,0.0000147733,0.00006420104,0.0002725336,0.000001287609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000156336,"about_ca_system_score_gemma":0.0004316006,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005282833,"about_ca_topic_score_gemma":0.02087572,"domain_scores_codex":[0.9976777,0.0003365815,0.0002924606,0.0008633402,0.0001089769,0.0007209395],"domain_scores_gemma":[0.9989978,0.00005416731,0.0001329804,0.0005345052,0.0001101063,0.0001704237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00376769,0.0008695397,0.1431699,0.00003100436,0.0009997699,0.000009746539,0.0008271035,0.00007671148,0.8400716,0.0003023173,0.0009641986,0.008910434],"study_design_scores_gemma":[0.0381597,0.01681182,0.1808072,0.0001835399,0.0001964292,0.00002328987,0.0005601697,0.0004862613,0.6652364,0.02522787,0.06980431,0.002503106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937285,0.002565491,0.0000753575,0.0009805306,0.0002176608,0.001396383,0.000701432,0.00002303547,0.0003115655],"genre_scores_gemma":[0.9924612,0.00326242,0.0001019751,0.001683333,0.000316951,0.001651339,0.0001938884,0.00005547576,0.0002734058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1748352,"threshold_uncertainty_score":0.9999503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04482851762084782,"score_gpt":0.3753929126132779,"score_spread":0.3305643949924301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}