{"id":"W2120191503","doi":"10.4161/cbt.213","title":"Human Tumor Xenografts as Predictive Preclinical Models for Anticancer Drug Activity in Humans: Better than Commonly Perceived—But They Can Be Improved","year":2003,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Cancer Institute; St. Jude Children's Research Hospital","keywords":"Medicine; In vivo; Cancer; Drug; Transplantation; Cancer research; Efficacy; Pharmacology; Oncology; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0324885,0.001194303,0.002144901,0.001279268,0.0006173042,0.007466539,0.001966463,0.002477813,0.004843906],"category_scores_gemma":[0.02156989,0.0009485612,0.0008210223,0.001750144,0.005312037,0.009490114,0.002067578,0.006918658,0.003295012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00121337,"about_ca_system_score_gemma":0.002046831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001488796,"about_ca_topic_score_gemma":0.00236289,"domain_scores_codex":[0.9820551,0.01243749,0.001050424,0.001116139,0.002946851,0.000393838],"domain_scores_gemma":[0.9713835,0.008169475,0.003964413,0.009946058,0.005254592,0.001282019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004746445,0.001617896,0.04776936,0.009442111,0.001103249,0.001430417,0.003794185,0.005066675,0.1603469,0.1912472,0.1413154,0.4321201],"study_design_scores_gemma":[0.0003463003,0.005580442,0.02424831,0.004935551,0.001019161,0.006586859,0.002330846,0.00409627,0.09223382,0.06465686,0.7934821,0.0004834719],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0705331,0.4627551,0.2802752,0.1137267,0.01588293,0.0009346146,0.006336038,0.003089268,0.04646707],"genre_scores_gemma":[0.457472,0.2970991,0.1666826,0.03715977,0.00809635,0.001217877,0.007333263,0.001590112,0.02334885],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0324885,"threshold_uncertainty_score":0.1718177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04482851762084782,"score_gpt":0.3753929126132779,"score_spread":0.3305643949924301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}