{"id":"W2120198923","doi":"10.1016/j.bmcl.2004.09.088","title":"Identification of a novel non-carbohydrate molecule that binds to the ribosomal A-site RNA","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Aminoglycoside; Binding site; Ribosomal RNA; Ribosome; Escherichia coli; A-site; RNA; Ribosomal protein; Biochemistry; Stereochemistry; Antibiotics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017627,0.0003227822,0.0002869408,0.0002987455,0.0003099898,0.000434039,0.0005775985,0.000738101,0.0018399],"category_scores_gemma":[0.0002378649,0.0001419776,0.0003479998,0.0002181514,0.0002306177,0.0001990284,0.0002868095,0.0005744675,0.0006148876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004041864,"about_ca_system_score_gemma":0.000257851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021527,"about_ca_topic_score_gemma":0.000802134,"domain_scores_codex":[0.9999148,0.00001138945,0.000002450951,0.00002127849,0.00001728885,0.0000328065],"domain_scores_gemma":[0.999864,0.0000417253,0.00001840992,0.00001420751,0.00001499253,0.00004673106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001107568,0.00003883059,0.0002795272,0.0000307172,0.000007306482,0.000359233,0.00001905945,0.0001041464,0.9957683,0.0005803671,0.00007610466,0.002625728],"study_design_scores_gemma":[0.00003642902,0.0004882583,0.007579091,0.00001063752,0.0000272924,0.000999148,0.00007992833,0.002913967,0.9791158,0.0005522386,0.008178609,0.00001864193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811566,0.001390163,0.01060228,0.0002952222,0.00009549755,0.00006507412,0.0003189615,0.00008287869,0.005993372],"genre_scores_gemma":[0.9837768,0.0005778497,0.009987382,0.0002903187,0.00004718393,0.0000469106,0.0006376517,0.00002099705,0.004614955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018399,"threshold_uncertainty_score":0.006155074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006142932671957,"score_gpt":0.22233009939042,"score_spread":0.2122686700637004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}