{"id":"W2120244315","doi":"10.1159/000149798","title":"Memantine Potentiates Agonist-Induced Ca&lt;sup&gt;2&amp;plus;&lt;/sup&gt; Responses in HEK 293 Cells","year":2008,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Université de Sherbrooke; Heart and Stroke Foundation of Canada","keywords":"Memantine; Agonist; Intracellular; NMDA receptor; Chemistry; Extracellular; Pharmacology; HEK 293 cells; Calcium in biology; Receptor; Biophysics; Cell biology; Endocrinology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001870576,0.000401101,0.0004760587,0.0001039717,0.000457257,0.00002740093,0.0003774724,0.0004643594,0.0002388228],"category_scores_gemma":[0.0001567274,0.0003444219,0.0001587401,0.0003198097,0.0006841261,0.00008543999,0.0002317161,0.0004188034,0.0001464102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003683057,"about_ca_system_score_gemma":0.0001231614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001812958,"about_ca_topic_score_gemma":0.000001844639,"domain_scores_codex":[0.9975687,0.0001894376,0.0004152869,0.0009626123,0.0002123698,0.0006515377],"domain_scores_gemma":[0.999038,0.0001780325,0.0001647044,0.0003855958,0.00005241332,0.0001812001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00022671,0.0001825204,0.00004443069,0.0001129093,0.00001093595,0.0001387465,0.0002727855,0.00006174592,0.9972537,0.00001598227,0.001632805,0.00004678982],"study_design_scores_gemma":[0.0007768789,0.00007714441,0.0001907646,0.00004559641,0.0000137671,0.0001162655,0.00006453349,0.0004749516,0.9948854,0.00009117005,0.002836778,0.000426773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981105,0.0005325414,0.000009593727,0.0002397614,0.0003649725,0.00022442,0.00004565622,0.00007382471,0.0003987393],"genre_scores_gemma":[0.9906685,0.0006190211,0.00006756306,0.0002696006,0.000361831,0.00002769115,0.00009174965,0.00003399538,0.007860093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007461354,"threshold_uncertainty_score":0.9999008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02549442772203075,"score_gpt":0.2363119405642174,"score_spread":0.2108175128421867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}