{"id":"W2120261661","doi":"10.1158/0008-5472.can-11-1659","title":"B Effector Cells Activated by a Chimeric Protein Consisting of IL-2 and the Ectodomain of TGF-β Receptor II Induce Potent Antitumor Immunity","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ectodomain; Antigen; Medicine; Cancer research; Immunology; CD8; Cytotoxic T cell; Tumor antigen; Molecular biology; Immune system; Biology; Receptor; Immunotherapy; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004771297,0.000165301,0.0005494165,0.0002228605,0.000274948,0.00001668299,0.0002644722,0.0001065367,0.001344846],"category_scores_gemma":[0.0009674922,0.0001106544,0.00009379168,0.0008371251,0.001489993,0.00008353039,0.0003604204,0.001080357,0.00001017868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123629,"about_ca_system_score_gemma":0.0004350863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004436781,"about_ca_topic_score_gemma":0.00001073083,"domain_scores_codex":[0.9962751,0.001396146,0.0003491892,0.0002487756,0.001017945,0.0007127929],"domain_scores_gemma":[0.9975842,0.0009711934,0.0001433924,0.0005685982,0.0004840147,0.0002485767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003585323,0.0002927434,0.001236588,0.0005069444,0.0001985969,0.000001805468,0.001134753,3.181919e-7,0.9830912,0.00004627053,0.001757885,0.008147593],"study_design_scores_gemma":[0.003705949,0.0006503266,0.00209002,0.0003963424,0.00002697276,0.000007041754,0.0003946535,0.00001379474,0.9886096,0.00001349385,0.003994329,0.00009748405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916444,0.004027272,0.000004596689,0.0007474777,0.0000723726,0.002627947,0.00008051042,0.00001700136,0.0007784298],"genre_scores_gemma":[0.9966093,0.000517021,0.00009731179,0.00002763481,0.0001369023,0.0003210852,0.00001248602,0.00004214448,0.002236067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008050109,"threshold_uncertainty_score":0.999568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05778358443386004,"score_gpt":0.3791564054011329,"score_spread":0.3213728209672729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}