{"id":"W2120261661","doi":"10.1158/0008-5472.can-11-1659","title":"B Effector Cells Activated by a Chimeric Protein Consisting of IL-2 and the Ectodomain of TGF-β Receptor II Induce Potent Antitumor Immunity","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ectodomain; Antigen; Medicine; Cancer research; Immunology; CD8; Cytotoxic T cell; Tumor antigen; Molecular biology; Immune system; Biology; Receptor; Immunotherapy; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468219,0.0005142961,0.0002793025,0.0002676545,0.00008598958,0.0003085171,0.0001264372,0.0002716012,0.001165073],"category_scores_gemma":[0.00005851577,0.000136557,0.0002841292,0.000118885,0.0001151526,0.0001446471,0.0001810987,0.0009327062,0.0005296667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113343,"about_ca_system_score_gemma":0.0001160536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001149579,"about_ca_topic_score_gemma":0.0001625556,"domain_scores_codex":[0.9998591,0.00001897745,0.00001071254,0.00002377556,0.00003547958,0.00005190253],"domain_scores_gemma":[0.9998962,0.00001528193,0.0000291104,0.00001345142,0.000009436443,0.00003660543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005257143,0.00003061801,0.00007814855,0.00001210314,0.000002329174,0.00002088732,0.000006062865,0.00001802733,0.9994267,0.00002088821,0.000008604555,0.0003231056],"study_design_scores_gemma":[0.00005311114,0.0006526947,0.003111701,0.000007697883,0.00002761325,0.0002861299,0.00002854968,0.0006436839,0.9929833,0.00003169766,0.002171129,0.000002677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959746,0.0007318713,0.001740581,0.00003225355,0.00002513088,0.00003785895,0.0001447217,0.00008809122,0.001224763],"genre_scores_gemma":[0.9942526,0.0006606863,0.001963388,0.00005073091,0.00001964469,0.0000482884,0.0005440491,0.00002193317,0.002438679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165073,"threshold_uncertainty_score":0.003897548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05778358443386004,"score_gpt":0.3791564054011329,"score_spread":0.3213728209672729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}