{"id":"W2120272156","doi":"10.1002/pro.2109","title":"Designing redox potential‐controlled protein switches based on mutually exclusive proteins","year":2012,"lang":"en","type":"article","venue":"Protein Science","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"Folding (DSP implementation); Molecular switch; Protein folding; Function (biology); Domain (mathematical analysis); Disulfide bond; Protein engineering; Protein domain; Redox; Protein design; Chemistry; Protein structure; Biophysics; Computational biology; Biology; Cell biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006072381,0.0002273303,0.0001948842,0.00008598698,0.0003267586,0.00009161733,0.0004344443,0.0001454751,0.00003464541],"category_scores_gemma":[0.0005062787,0.0001741844,0.00009424508,0.0003207207,0.0003077621,0.00003620781,0.0001428514,0.0001412422,0.00001499157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002903567,"about_ca_system_score_gemma":0.0001714836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003984686,"about_ca_topic_score_gemma":3.168718e-7,"domain_scores_codex":[0.9981148,0.00007096327,0.0002628702,0.0005118422,0.0004646123,0.0005749493],"domain_scores_gemma":[0.9990692,0.000006280016,0.0001770198,0.0003827933,0.0001423446,0.0002224255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003968379,0.00006023506,0.0001163665,0.00001764719,0.000005804255,8.181703e-7,0.00003384792,0.0000239877,0.9978118,0.0001184699,0.000006092595,0.001408117],"study_design_scores_gemma":[0.00101595,0.0002981263,0.0009403503,0.00005056739,0.00000730981,0.000004265049,0.00002285422,0.0006605392,0.9964139,0.0001386141,0.0001866908,0.0002608168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735048,0.00009444577,0.02293322,0.0004338397,0.0001044743,0.002068297,0.000005885463,0.00003650276,0.0008184924],"genre_scores_gemma":[0.9866332,0.000001261807,0.01177788,0.0002706278,0.0003579103,0.0004599046,0.00002656348,0.0000180883,0.0004545563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01312837,"threshold_uncertainty_score":0.7103036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008457215400969852,"score_gpt":0.2330783605358913,"score_spread":0.2246211451349215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}