{"id":"W2120272156","doi":"10.1002/pro.2109","title":"Designing redox potential‐controlled protein switches based on mutually exclusive proteins","year":2012,"lang":"en","type":"article","venue":"Protein Science","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"Folding (DSP implementation); Molecular switch; Protein folding; Function (biology); Domain (mathematical analysis); Disulfide bond; Protein engineering; Protein domain; Redox; Protein design; Chemistry; Protein structure; Biophysics; Computational biology; Biology; Cell biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003350597,0.0002791609,0.0002476767,0.0001999361,0.0001841154,0.0004470218,0.0004043007,0.000302827,0.0005855096],"category_scores_gemma":[0.0002823795,0.0002597349,0.0002037834,0.0001828282,0.0003891009,0.0005122686,0.0003793907,0.0004494626,0.0001773933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002853277,"about_ca_system_score_gemma":0.0002038089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001291884,"about_ca_topic_score_gemma":0.0002890776,"domain_scores_codex":[0.99986,0.00002741218,0.00001310898,0.00003380916,0.00004094403,0.00002457151],"domain_scores_gemma":[0.9998667,0.00003329865,0.00003898721,0.00001543498,0.00001561582,0.00002989681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001009388,0.00004415265,0.000214172,0.0000513999,0.00001024197,0.00007879795,0.00003508145,0.001164211,0.9914964,0.003225846,0.00004988733,0.003528837],"study_design_scores_gemma":[0.00003327025,0.0001586799,0.0002984385,0.000003935667,0.00001309237,0.0001007805,0.00001857489,0.008174412,0.9869647,0.0005760458,0.003643537,0.00001458798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751083,0.000836071,0.02097558,0.0001313849,0.00005306204,0.00006235789,0.00006646882,0.0001080105,0.002658866],"genre_scores_gemma":[0.9740856,0.000804718,0.02316928,0.00009281705,0.00001333092,0.00008194552,0.00008249723,0.00002584198,0.001643932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005855096,"threshold_uncertainty_score":0.002070189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008457215400969852,"score_gpt":0.2330783605358913,"score_spread":0.2246211451349215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}