{"id":"W2120298753","doi":"10.1093/brain/awv080","title":"Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Stichting Zabawas; Child and Family Research Institute","keywords":"Antigen; Immunology; Multiple sclerosis; CIITA; Biology; Peripheral blood mononuclear cell; Human leukocyte antigen; Endosome; Immune system; Cell biology; Medicine; MHC class II; Genetics; Major histocompatibility complex; In vitro; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001401864,0.0002307741,0.0003072251,0.0002021414,0.0001956238,0.0002562333,0.0001134953,0.000227444,0.00138275],"category_scores_gemma":[0.0001893237,0.0001286586,0.0002398359,0.0001370546,0.0002502827,0.0001336665,0.000240826,0.0003047626,0.0005456458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002591281,"about_ca_system_score_gemma":0.0001791439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006684309,"about_ca_topic_score_gemma":0.000660523,"domain_scores_codex":[0.9998573,0.00003091257,0.00001782726,0.00004339706,0.00001969767,0.00003083331],"domain_scores_gemma":[0.9998228,0.00001369755,0.00005717685,0.00002810973,0.00003137123,0.00004689101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002586755,0.00001541869,0.001153019,0.00002682587,0.000005778453,0.00006539436,0.00002642857,0.00002118867,0.9976379,0.00003263753,0.00003304948,0.0007236899],"study_design_scores_gemma":[0.00009480554,0.0004863067,0.1185852,0.00002787597,0.00004557013,0.001390237,0.0001905358,0.001800921,0.8716266,0.0002461563,0.005490269,0.0000154744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977841,0.0008511852,0.000645166,0.00004515328,0.0000146513,0.00001041093,0.0001952752,0.00003325006,0.0004208803],"genre_scores_gemma":[0.9972735,0.0003548031,0.0006856058,0.00002370232,0.000005885818,0.00002025904,0.0002204998,0.00001554405,0.001400092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00138275,"threshold_uncertainty_score":0.004625738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03017328495267013,"score_gpt":0.221090689285376,"score_spread":0.1909174043327058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}