{"id":"W2120298753","doi":"10.1093/brain/awv080","title":"Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis","year":2015,"lang":"en","type":"article","venue":"Brain","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Stichting Zabawas; Child and Family Research Institute","keywords":"Antigen; Immunology; Multiple sclerosis; CIITA; Biology; Peripheral blood mononuclear cell; Human leukocyte antigen; Endosome; Immune system; Cell biology; Medicine; MHC class II; Genetics; Major histocompatibility complex; In vitro; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005239018,0.0003340284,0.0005547168,0.0001615767,0.0004233879,0.00002187471,0.0004309484,0.0007448162,0.0003424508],"category_scores_gemma":[0.0004924521,0.0002895312,0.0001860672,0.0002238112,0.000293699,0.0001313842,0.0003136996,0.0003749225,0.001693919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001023595,"about_ca_system_score_gemma":0.00008961063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000397229,"about_ca_topic_score_gemma":0.0001394193,"domain_scores_codex":[0.9974949,0.0006936984,0.0004723735,0.0005014537,0.00006919101,0.000768369],"domain_scores_gemma":[0.9986063,0.0004434016,0.0002552602,0.000480136,0.0001343677,0.00008058165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000401384,0.000431529,0.002207831,0.000004289272,0.0001929287,0.000009332172,0.0004707249,0.000008326492,0.9626736,0.00006349986,0.03091362,0.002622929],"study_design_scores_gemma":[0.009859342,0.0004869545,0.002881021,0.00005366911,0.00004741558,0.00002504317,0.0001540429,0.00004115638,0.8561456,0.0002629081,0.1296522,0.0003905842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913917,0.003671087,0.0001257609,0.001641946,0.001367046,0.0004051407,0.0001187821,0.0003228745,0.00095562],"genre_scores_gemma":[0.9835476,0.00005800607,0.0000674536,0.001063759,0.00005790213,0.00006768641,0.0004001656,0.00004468015,0.0146928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.106528,"threshold_uncertainty_score":0.9999557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03017328495267013,"score_gpt":0.221090689285376,"score_spread":0.1909174043327058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}