{"id":"W2120303261","doi":"10.1182/blood-2014-12-618363","title":"Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Beth Israel Deaconess Medical Center","keywords":"Autoimmunity; Nod; Immunology; Haematopoiesis; FOXP3; Immune system; Stem cell; Humanized mouse; Major histocompatibility complex; Biology; Medicine; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002334607,0.0001508625,0.0002175611,0.000139242,0.0001436046,0.0000191579,0.0001234148,0.0001569101,0.0002331381],"category_scores_gemma":[0.00001575376,0.0001333708,0.00004623092,0.0001567355,0.0001207493,0.0001876018,0.0000486429,0.0004214058,0.0005520432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007150444,"about_ca_system_score_gemma":0.00007536299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000381022,"about_ca_topic_score_gemma":0.0001285683,"domain_scores_codex":[0.9990667,0.0002116822,0.000239337,0.0002160143,0.00002969174,0.0002366156],"domain_scores_gemma":[0.9995293,0.00006128378,0.0001096093,0.0001948649,0.00008323527,0.00002171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002100341,0.0006586006,0.00267219,0.00001805452,0.0001855743,0.00001969288,0.002148282,0.00001613239,0.9921635,0.0004323327,0.001306462,0.0001691169],"study_design_scores_gemma":[0.00540418,0.0004742605,0.0009514976,0.0001118541,0.00008758209,0.0004224316,0.003734052,0.000002687853,0.9830539,0.00003677531,0.005477281,0.0002434555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813308,0.0005523469,0.0001085811,0.00001772654,0.001104734,0.0002232774,0.000002663575,0.00009583598,0.01656409],"genre_scores_gemma":[0.9959283,0.000006744469,0.00003145139,0.00004779813,0.00001372506,0.00002250223,0.00004240772,0.00001278564,0.003894255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01459759,"threshold_uncertainty_score":0.7095582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02498019508134009,"score_gpt":0.2328533231229001,"score_spread":0.20787312804156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}