{"id":"W2120303261","doi":"10.1182/blood-2014-12-618363","title":"Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Beth Israel Deaconess Medical Center","keywords":"Autoimmunity; Nod; Immunology; Haematopoiesis; FOXP3; Immune system; Stem cell; Humanized mouse; Major histocompatibility complex; Biology; Medicine; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003882418,0.0007411102,0.0002534486,0.0008247269,0.0002731114,0.0004531039,0.0001877061,0.0005489534,0.002361306],"category_scores_gemma":[0.000190614,0.0002688271,0.0002926529,0.0001878752,0.0005070408,0.0002848743,0.0002454563,0.0008968479,0.0004014895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003070995,"about_ca_system_score_gemma":0.0003091021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004768485,"about_ca_topic_score_gemma":0.0005764024,"domain_scores_codex":[0.9997215,0.00005662097,0.00003194314,0.00008095348,0.00006144595,0.0000475607],"domain_scores_gemma":[0.9997175,0.00005184942,0.00009847947,0.00003483732,0.00001443399,0.00008288152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003127078,0.0001152438,0.0005520392,0.0000307335,0.00001618251,0.0004503451,0.00005073916,0.0001627104,0.995988,0.0006929087,0.0001478108,0.001480574],"study_design_scores_gemma":[0.0002552278,0.001639161,0.007859688,0.00003851409,0.00008307136,0.006503566,0.00007499141,0.003379246,0.9737978,0.000700126,0.005649684,0.00001877967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908357,0.0007755829,0.005442031,0.000163486,0.0000580178,0.00005338615,0.0006503483,0.0004377858,0.001583737],"genre_scores_gemma":[0.9917134,0.0006139419,0.003041338,0.0001102646,0.0000198044,0.0000813335,0.0006935467,0.00007338115,0.003652908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002361306,"threshold_uncertainty_score":0.007899344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02498019508134009,"score_gpt":0.2328533231229001,"score_spread":0.20787312804156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}