{"id":"W2120316424","doi":"10.4049/jimmunol.1003487","title":"IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF-α–Mediated Bone Loss","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Versus Arthritis; Wellcome Trust","keywords":"Osteoclast; Bone marrow; Autocrine signalling; Bone resorption; Bone remodeling; Cell biology; Chemistry; Tumor necrosis factor alpha; Cytokine; Inflammation; Immunology; Endocrinology; Receptor; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150865,0.0005247691,0.0003574264,0.0002873753,0.0001073373,0.0002384517,0.0001601335,0.0002636975,0.0007962134],"category_scores_gemma":[0.00009698001,0.0001399693,0.0002843734,0.0001310283,0.0002373038,0.0001734226,0.0001846838,0.001130844,0.0001943387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001173452,"about_ca_system_score_gemma":0.0002611674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000404672,"about_ca_topic_score_gemma":0.000592549,"domain_scores_codex":[0.9998615,0.00002286854,0.00001318158,0.00001863715,0.00003607738,0.00004763496],"domain_scores_gemma":[0.9998916,0.00001078545,0.00004002723,0.0000145787,0.00000911198,0.00003383084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004988892,0.000073679,0.0001512903,0.00003829802,0.000005999491,0.00005729558,0.0000119945,0.00008538042,0.9975142,0.00005447042,0.00003422134,0.001474291],"study_design_scores_gemma":[0.0001425362,0.002951533,0.005379628,0.00002282561,0.00004996919,0.0004244077,0.00005559769,0.0008705349,0.9867414,0.0001237511,0.003227878,0.000009923954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942495,0.002241972,0.002505642,0.0001255765,0.0000578608,0.00003306973,0.0001922019,0.00009348261,0.0005007662],"genre_scores_gemma":[0.9958912,0.001278035,0.001257755,0.00008014016,0.00001834828,0.00003267966,0.0002967838,0.00001115613,0.001133901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007962134,"threshold_uncertainty_score":0.002663553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01505670520915519,"score_gpt":0.2055813932293624,"score_spread":0.1905246880202072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}