{"id":"W2120322365","doi":"10.1089/hum.2004.15.906","title":"Long-Term Correction of Murine Lipoprotein Lipase Deficiency with AAV1-Mediated Gene Transfer of the Naturally Occurring LPL <sup>S447X</sup> Beneficial Mutation","year":2004,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Lipoprotein lipase; Endocrinology; Internal medicine; Hypertriglyceridemia; Hyperlipidemia; Dyslipidemia; Triglyceride; Skeletal muscle; Biology; Medicine; Cholesterol; Adipose tissue","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154011,0.0001942492,0.0001942932,0.00005542673,0.0001313301,0.00001449919,0.0002151768,0.0001404144,0.00002411653],"category_scores_gemma":[0.0000123228,0.0001449208,0.0001369682,0.0001975915,0.0001070088,0.000008526211,0.0000227426,0.0001100128,0.000001115432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002391092,"about_ca_system_score_gemma":0.00008878818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001552927,"about_ca_topic_score_gemma":0.000273316,"domain_scores_codex":[0.9989215,0.00004866436,0.0002924341,0.0002754949,0.000224475,0.0002374524],"domain_scores_gemma":[0.9993989,0.000006556066,0.0001390878,0.0002728542,0.000143008,0.00003957422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002551805,0.0003495381,0.00411164,0.00002452298,0.0001044588,0.00000194963,0.0005921925,0.01362373,0.9756039,0.00002010564,0.000008256676,0.005304475],"study_design_scores_gemma":[0.002846984,0.001154833,0.03351758,0.00005120044,0.00003366303,0.000006044068,0.0001047724,0.00006259682,0.9619299,0.0000438551,0.00003467041,0.0002138765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976771,0.001324801,0.0003294754,0.0000276244,0.00009416899,0.0004042425,0.00003380379,0.00001612209,0.00009265268],"genre_scores_gemma":[0.999253,0.0001877545,0.00005835596,0.0001046621,0.0000924615,0.00002225809,0.0002120057,0.00003067448,0.00003886886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02940594,"threshold_uncertainty_score":0.59097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006713856505483853,"score_gpt":0.2198921195289212,"score_spread":0.2131782630234373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}