{"id":"W2120322365","doi":"10.1089/hum.2004.15.906","title":"Long-Term Correction of Murine Lipoprotein Lipase Deficiency with AAV1-Mediated Gene Transfer of the Naturally Occurring LPL <sup>S447X</sup> Beneficial Mutation","year":2004,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Lipoprotein lipase; Endocrinology; Internal medicine; Hypertriglyceridemia; Hyperlipidemia; Dyslipidemia; Triglyceride; Skeletal muscle; Biology; Medicine; Cholesterol; Adipose tissue","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004022024,0.0006466524,0.0003718772,0.0003469912,0.0001549265,0.0004053285,0.00036845,0.0005363674,0.001038143],"category_scores_gemma":[0.0001881067,0.0002167312,0.0003613066,0.0001451842,0.0004243359,0.0003548598,0.0003398786,0.001122509,0.0005761755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000348978,"about_ca_system_score_gemma":0.0003898805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004015823,"about_ca_topic_score_gemma":0.0005437827,"domain_scores_codex":[0.9996432,0.0000613198,0.0000607401,0.00007618791,0.00009476081,0.00006371066],"domain_scores_gemma":[0.9996493,0.00003988376,0.0001315825,0.0000394376,0.00004290176,0.00009697426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031051,0.00008291807,0.000133853,0.0000255787,0.000007058159,0.000057476,0.00001848835,0.00008135191,0.9970765,0.0001289336,0.00006072164,0.002224011],"study_design_scores_gemma":[0.00008941798,0.002214006,0.001941595,0.00001417949,0.00004199806,0.0005884288,0.00004327436,0.001778296,0.988616,0.00008701337,0.004573304,0.00001251809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886116,0.001031328,0.008266574,0.0002279926,0.00009481487,0.0000834772,0.0004480916,0.0004262844,0.0008097136],"genre_scores_gemma":[0.9789212,0.00107888,0.0115147,0.0001363347,0.00005653201,0.0001783954,0.001363987,0.0001209063,0.006629007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038143,"threshold_uncertainty_score":0.003472924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006713856505483853,"score_gpt":0.2198921195289212,"score_spread":0.2131782630234373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}