{"id":"W2120327160","doi":"10.1124/dmd.113.054213","title":"Two Polymorphic Variants of ABCC1 Selectively Alter Drug Resistance and Inhibitor Sensitivity of the Multidrug and Organic Anion Transporter Multidrug Resistance Protein 1","year":2013,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Vrije Universiteit Amsterdam","keywords":"ABCC1; Efflux; Calcein; Organic anion-transporting polypeptide; Multidrug Resistance-Associated Proteins; ATP-binding cassette transporter; Multidrug resistance-associated protein 2; Multiple drug resistance; Mutant; Biochemistry; Biology; HEK 293 cells; Chemistry; Wild type; Abcg2; Transporter; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004065157,0.001353607,0.0006962075,0.0009542888,0.0005442444,0.0004978589,0.0005924242,0.001629189,0.004218171],"category_scores_gemma":[0.001840031,0.0003012108,0.0004608288,0.0006378952,0.0009065688,0.0002769951,0.0005446811,0.001225265,0.0003994798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000529062,"about_ca_system_score_gemma":0.0002640563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002316747,"about_ca_topic_score_gemma":0.00182601,"domain_scores_codex":[0.999239,0.0002332468,0.0000848733,0.0002114098,0.0001226378,0.0001087555],"domain_scores_gemma":[0.9986888,0.0006545107,0.0003077413,0.00007733608,0.0001010472,0.0001705176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00963436,0.0009324779,0.08646023,0.0002032101,0.0007424942,0.02976191,0.001414321,0.001456251,0.8357118,0.005889142,0.002279109,0.02551468],"study_design_scores_gemma":[0.002600233,0.003338859,0.6526505,0.0001753308,0.001427108,0.08989066,0.0008046373,0.01174081,0.218863,0.003937262,0.01415349,0.000418201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965418,0.0002511225,0.001267812,0.0003331599,0.00005552861,0.00004244193,0.0004959371,0.00004186378,0.0009703595],"genre_scores_gemma":[0.9981579,0.00005928774,0.0007470244,0.0001432667,0.00003191953,0.00001775451,0.0002069871,0.0000447291,0.0005911568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004218171,"threshold_uncertainty_score":0.01411116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003844285576560692,"score_gpt":0.197901365295073,"score_spread":0.1940570797185124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}