{"id":"W2120383264","doi":"10.1155/2015/647389","title":"Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort","year":2015,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Key Scientific Instrument and Equipment Development Projects of China; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Genentech; Fundamental Research Funds for the Central Universities; National Institutes of Health; Servier; National Natural Science Foundation of China; Eisai; Harbin Engineering University; U.S. National Library of Medicine; IXICO; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Higher Education Discipline Innovation Project; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Association; National Science Foundation","keywords":"Genome-wide association study; Missing heritability problem; Alzheimer's Disease Neuroimaging Initiative; Bioinformatics; Single-nucleotide polymorphism; Computational biology; Genetics; Medicine; Biology; Disease; Genotype; Internal medicine; Gene; Alzheimer's disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001198865,0.0006066287,0.0006480807,0.0003883081,0.001124491,0.0009453284,0.0005505337,0.0006071913,0.001697461],"category_scores_gemma":[0.002491783,0.0005008861,0.0009512043,0.0007296024,0.000421449,0.0002622268,0.0005580724,0.0008320176,0.0002912603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003871994,"about_ca_system_score_gemma":0.0004140018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0124725,"about_ca_topic_score_gemma":0.01902912,"domain_scores_codex":[0.9992362,0.0002708435,0.00005135083,0.0002594106,0.00008873525,0.00009343708],"domain_scores_gemma":[0.9992781,0.0001849562,0.00013052,0.0002357536,0.00005725175,0.0001133367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002642026,0.0002092715,0.9834473,0.00002880241,0.001394213,0.00116963,0.0005471555,0.0002888759,0.004915405,0.0003631662,0.000872898,0.004121132],"study_design_scores_gemma":[0.00008993948,0.0001283361,0.996515,0.000005932593,0.0006717539,0.000693149,0.0001322368,0.0007380366,0.0002786035,0.000249232,0.0004833617,0.00001438691],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985151,0.0002033556,0.0003487043,0.00007651441,0.00001137088,0.000009096052,0.0003937586,0.0000155078,0.0004265762],"genre_scores_gemma":[0.9989488,0.00006146818,0.0003419411,0.00003099412,0.00001452154,0.00001264633,0.0003432239,0.00001237081,0.0002340344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0124725,"threshold_uncertainty_score":0.02479982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08792582788611057,"score_gpt":0.4206674622616013,"score_spread":0.3327416343754907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}