{"id":"W2120383264","doi":"10.1155/2015/647389","title":"Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort","year":2015,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Key Scientific Instrument and Equipment Development Projects of China; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Genentech; Fundamental Research Funds for the Central Universities; National Institutes of Health; Servier; National Natural Science Foundation of China; Eisai; Harbin Engineering University; U.S. National Library of Medicine; IXICO; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Higher Education Discipline Innovation Project; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Association; National Science Foundation","keywords":"Genome-wide association study; Missing heritability problem; Alzheimer's Disease Neuroimaging Initiative; Bioinformatics; Single-nucleotide polymorphism; Computational biology; Genetics; Medicine; Biology; Disease; Genotype; Internal medicine; Gene; Alzheimer's disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003077541,0.000149149,0.0002014978,0.001023242,0.0001157726,0.0001903122,0.000280406,0.00005239692,0.0001713952],"category_scores_gemma":[0.00152864,0.0001168199,0.00004095988,0.000650904,0.00008636211,0.0004087795,0.0001396906,0.0006421133,0.00009451694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001574273,"about_ca_system_score_gemma":0.0003266878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001954689,"about_ca_topic_score_gemma":0.001248603,"domain_scores_codex":[0.9960101,0.0009791445,0.0003832798,0.0004470385,0.001719914,0.0004605564],"domain_scores_gemma":[0.99808,0.000621736,0.00009179189,0.000299271,0.0005767083,0.0003305505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008190654,0.001949874,0.9904037,0.0000102077,0.001036118,0.00086605,0.002774968,0.00003579441,0.000236581,0.0000279835,0.0009334672,0.00090622],"study_design_scores_gemma":[0.003209244,0.0006324421,0.9839342,0.00005277335,0.00003694898,0.00007185134,0.006211024,0.002928787,0.00002285666,0.0003418442,0.002458488,0.00009951917],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921495,0.0002518253,0.00002543588,0.003954378,0.0003260612,0.001422114,0.00003236947,0.00002070904,0.00181766],"genre_scores_gemma":[0.998149,0.000126218,0.0001550845,0.00008941591,0.0004190316,0.000456766,0.0001955484,0.00001942228,0.0003895359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006469449,"threshold_uncertainty_score":0.4763778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08792582788611057,"score_gpt":0.4206674622616013,"score_spread":0.3327416343754907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}