{"id":"W2120386191","doi":"10.1186/gm249","title":"The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease","year":2011,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"National Institute on Aging; Instituto de Salud Carlos III; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; University of California, Los Angeles; Genentech; National Institutes of Health; Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; Junta de Andalucía; Eisai; Northern California Institute for Research and Education; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; Medpace; GlaxoSmithKline; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Pfizer; Corporación Tecnológica de Andalucía; Elan; Novartis; Synarc; Dana Foundation; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Odds ratio; Genetics; Biology; Genetic association; Imputation (statistics); Population; Meta-analysis; Subfamily; Gene; Medicine; Single-nucleotide polymorphism; Genotype; Internal medicine; Computer science; Missing data","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009556168,0.0006248594,0.0006895566,0.001117912,0.0004399816,0.0005220551,0.0005129654,0.0004604336,0.003323984],"category_scores_gemma":[0.002438345,0.0001685894,0.0007217192,0.001942142,0.0003431585,0.0001882361,0.0003956383,0.0002735354,0.0002423923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004582255,"about_ca_system_score_gemma":0.0004686175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005265546,"about_ca_topic_score_gemma":0.004662405,"domain_scores_codex":[0.9993601,0.000192543,0.00006958967,0.0002439211,0.00009375082,0.00004003111],"domain_scores_gemma":[0.9988399,0.0005054997,0.0003584567,0.000130805,0.0001036867,0.00006163634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00252206,0.00007078116,0.9446282,0.0002972139,0.003125655,0.000849738,0.0001296189,0.001267954,0.03196348,0.0001804272,0.0005787389,0.01438615],"study_design_scores_gemma":[0.0001632385,0.0001625165,0.9881072,0.00003484223,0.001711255,0.001350675,0.00009015807,0.001947727,0.004438478,0.0006528171,0.001326088,0.00001512024],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948757,0.001493918,0.001730467,0.0001248449,0.00001469649,0.00001877208,0.001373561,0.00003571949,0.0003322162],"genre_scores_gemma":[0.9972796,0.0003576651,0.001196209,0.00003419006,0.00002392558,0.00001656,0.0008712215,0.000009187995,0.0002115338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005265546,"threshold_uncertainty_score":0.01111978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02553347686892772,"score_gpt":0.2469908264309748,"score_spread":0.221457349562047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}