{"id":"W2120403234","doi":"10.1534/genetics.109.107631","title":"Telomerase Is Essential to Alleviate Pif1-Induced Replication Stress at Telomeres","year":2009,"lang":"en","type":"article","venue":"Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Oncosuisse; European Commission; Canadian Institutes of Health Research; Genome Canada; Seventh Framework Programme; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Telomere; Telomerase; DNA replication; DNA damage; Replication protein A; Molecular biology; Genetics; Control of chromosome duplication; DNA; Cell biology; Gene; DNA-binding protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000110322,0.0002019809,0.0001441485,0.00005550915,0.0001004386,0.00003251625,0.0003025911,0.0001767415,0.00007343],"category_scores_gemma":[0.00005385583,0.0002145209,0.00009006538,0.0001219785,0.00001756261,0.00000229564,0.0001805154,0.00006022586,0.0001338291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002901021,"about_ca_system_score_gemma":0.00004325034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005894763,"about_ca_topic_score_gemma":0.00003763356,"domain_scores_codex":[0.9985055,0.00003904058,0.0002483523,0.0006611215,0.0002126652,0.0003333295],"domain_scores_gemma":[0.9984561,0.000004410428,0.00008548333,0.001159451,0.0001068347,0.0001877131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004674335,0.00006596201,0.0002522399,0.000006158357,0.00002476338,0.000003355057,0.00008257204,0.00006294272,0.9765792,0.00002784569,0.005937194,0.01691102],"study_design_scores_gemma":[0.0002776311,0.0004558435,0.002590894,0.000008424384,0.00002118353,0.00001120394,0.00002185828,0.0000688131,0.9648198,0.0001184013,0.03134554,0.0002603986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996716,0.0003139132,0.0008393421,0.000843853,0.000148876,0.0003320074,0.00004335243,0.00003976519,0.0007228517],"genre_scores_gemma":[0.9909575,0.0001683582,0.004508298,0.002050888,0.0003239488,0.00002319878,0.0001491393,0.00003131866,0.001787359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02540834,"threshold_uncertainty_score":0.8747908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01205218621519062,"score_gpt":0.2763981506213734,"score_spread":0.2643459644061828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}