{"id":"W2120406088","doi":"10.1002/anie.200462092","title":"Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal‐RNA Decoding Site","year":2004,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"RNA; Binding site; Ribosomal RNA; Chemistry; Paromomycin; A-site; Stereochemistry; Biochemistry; Antibiotics; Aminoglycoside; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325763,0.0002850194,0.0003531072,0.00007863066,0.000131831,0.0002883064,0.0003918438,0.000339736,0.0007143517],"category_scores_gemma":[0.0001918625,0.0001753221,0.0001324577,0.00007623874,0.0002756883,0.000191179,0.0001591735,0.0004681868,0.0003535139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000216995,"about_ca_system_score_gemma":0.0001728423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002558935,"about_ca_topic_score_gemma":0.0004994598,"domain_scores_codex":[0.9998854,0.00002659094,0.000009161922,0.00001803457,0.00003081933,0.00002982432],"domain_scores_gemma":[0.9999154,0.00001704497,0.00002233859,0.00001683002,0.000009594494,0.00001891519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002022602,0.00001848622,0.0001077373,0.00003430146,0.00000412821,0.0001114228,0.00002279983,0.0002163804,0.9950023,0.000813857,0.00005851324,0.003407788],"study_design_scores_gemma":[0.00007956292,0.0007928354,0.0008779216,0.000005810496,0.00001794941,0.0003893906,0.00001428273,0.00124673,0.9933378,0.000193685,0.003030264,0.0000137666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915012,0.001119022,0.003643862,0.0001085796,0.00006596033,0.00002417465,0.00004879536,0.0001471208,0.003341236],"genre_scores_gemma":[0.9955938,0.0004971169,0.002551958,0.00007451839,0.00002754944,0.00001928291,0.00004426599,0.00002117499,0.001170328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007143517,"threshold_uncertainty_score":0.002389789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01238663339647335,"score_gpt":0.2515213065714754,"score_spread":0.2391346731750021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}