{"id":"W2120410890","doi":"10.3390/11060393","title":"Synthesis and Analgesic Activity Evaluation of Some Agmatine Derivatives","year":2006,"lang":"en","type":"article","venue":"Molecules","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Research Nova Scotia","keywords":"Agmatine; Analgesic; Permeation; Chemistry; In vivo; Diamine; Blood–brain barrier; Pharmacology; Combinatorial chemistry; Organic chemistry; Medicine; Biochemistry; Central nervous system; Internal medicine; Membrane; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008415743,0.0002851156,0.000195507,0.0001924845,0.0001358299,0.00009536689,0.000208013,0.000146455,0.001189405],"category_scores_gemma":[0.0001084428,0.00007687409,0.0001183427,0.0001638739,0.0001164331,0.0001360664,0.00009329162,0.0002271386,0.0001613332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002188259,"about_ca_system_score_gemma":0.0001890228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004958024,"about_ca_topic_score_gemma":0.001338898,"domain_scores_codex":[0.9999501,0.00001201835,0.000005199675,0.00000876646,0.00001212894,0.00001176818],"domain_scores_gemma":[0.9999418,0.000007615331,0.00001709853,0.00000514308,0.00001373011,0.00001471351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001134214,0.00003814172,0.00008107349,0.0001156171,0.000005109641,0.0000815238,0.00002422136,0.0002835386,0.9948493,0.0002058581,0.00005695019,0.004145313],"study_design_scores_gemma":[0.00002942655,0.001375554,0.001338379,0.000008189433,0.00002192706,0.000198871,0.00001310476,0.0003873224,0.9934126,0.00004205418,0.003165059,0.000007645303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864803,0.00469872,0.00409233,0.0001162681,0.00003243444,0.00009523472,0.0004700483,0.00007012999,0.003944468],"genre_scores_gemma":[0.9897966,0.002705553,0.004786176,0.0000549728,0.00001528118,0.00005225081,0.0003764167,0.00001059971,0.002202181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189405,"threshold_uncertainty_score":0.003978968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479594769996213,"score_gpt":0.2492365055000232,"score_spread":0.2344405578000611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}