{"id":"W2120410890","doi":"10.3390/11060393","title":"Synthesis and Analgesic Activity Evaluation of Some Agmatine Derivatives","year":2006,"lang":"en","type":"article","venue":"Molecules","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Research Nova Scotia","keywords":"Agmatine; Analgesic; Permeation; Chemistry; In vivo; Diamine; Blood–brain barrier; Pharmacology; Combinatorial chemistry; Organic chemistry; Medicine; Biochemistry; Central nervous system; Internal medicine; Membrane; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002402133,0.0001254813,0.0001587054,0.00004401119,0.00005788208,0.00001704098,0.00006658943,0.000065616,0.00001703061],"category_scores_gemma":[0.0001250825,0.0001078059,0.00005734653,0.00005185578,0.0001027397,0.000009651601,0.00004857042,0.00002845423,7.588686e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006257945,"about_ca_system_score_gemma":0.00003395256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008757732,"about_ca_topic_score_gemma":0.00003294914,"domain_scores_codex":[0.9992375,0.0001022373,0.0001367042,0.0002080076,0.0001905183,0.0001250137],"domain_scores_gemma":[0.9995751,0.00003284424,0.000109377,0.0001648145,0.00009526832,0.00002260066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003020077,0.00008626231,0.00121544,0.00003015253,0.00003112775,2.986035e-7,0.00001179385,0.0000846391,0.976963,0.0006894537,0.0001825996,0.02067502],"study_design_scores_gemma":[0.0001940719,0.00005011841,0.07588618,0.00002070982,0.00005692601,0.00000241732,0.00003780738,0.0006129011,0.9212992,0.001267752,0.0004413858,0.0001305291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954361,0.002259021,0.0004812899,0.0001492211,0.00002774456,0.0001010649,0.00002241864,0.00000717997,0.001515943],"genre_scores_gemma":[0.9992416,0.00009611677,0.0003716174,0.00002844051,0.0001384237,0.00002922711,0.00001438299,0.00001322018,0.00006696532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07467074,"threshold_uncertainty_score":0.4396197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479594769996213,"score_gpt":0.2492365055000232,"score_spread":0.2344405578000611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}