{"id":"W2120428000","doi":"10.1093/hmg/dds400","title":"Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Endoplasmic reticulum; HEK 293 cells; Protein subunit; Cell biology; Unfolded protein response; Cell culture; Molecular biology; Receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006433101,0.0005164559,0.0003734306,0.0002832032,0.0002868801,0.0003072564,0.0002007094,0.000411553,0.00108195],"category_scores_gemma":[0.000128154,0.000145975,0.0002752206,0.0002567201,0.0001874187,0.0002058735,0.0002381286,0.0002555938,0.0006396625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004108789,"about_ca_system_score_gemma":0.0001300988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009628168,"about_ca_topic_score_gemma":0.001054218,"domain_scores_codex":[0.9999063,0.000007770773,0.000007730283,0.00003701788,0.00002624555,0.00001491466],"domain_scores_gemma":[0.9999375,0.000006177552,0.00002742856,0.000004215473,0.000008605703,0.00001610765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007223333,0.00001095154,0.002606133,0.00008179287,0.00001757364,0.0005024465,0.00003094121,0.0000869742,0.9920499,0.0002232866,0.0002395632,0.004078159],"study_design_scores_gemma":[0.00001745274,0.0001687193,0.04902964,0.00002945325,0.00006543469,0.007655291,0.000121217,0.002398078,0.9163842,0.0004630327,0.02364899,0.00001848311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838738,0.008563397,0.004629658,0.0001870739,0.00006028379,0.00001574749,0.0009004025,0.0002402885,0.001529378],"genre_scores_gemma":[0.9915041,0.001911326,0.001541765,0.00004092599,0.00001274192,0.00000979767,0.001608396,0.00002085652,0.00335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00108195,"threshold_uncertainty_score":0.003619432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01640033050213852,"score_gpt":0.2655236404027602,"score_spread":0.2491233099006216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}