{"id":"W2120506391","doi":"10.1016/j.pbb.2005.08.008","title":"Ultra-low-dose naltrexone reduces the rewarding potency of oxycodone and relapse vulnerability in rats","year":2005,"lang":"en","type":"article","venue":"Pharmacology Biochemistry and Behavior","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Goddard Space Flight Center","keywords":"Oxycodone; Opioid; Naltrexone; Pharmacology; Self-administration; Medicine; Anesthesia; Potency; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003981118,0.0002420507,0.00028653,0.00006321057,0.0001780936,0.00002522825,0.0003163922,0.0001443013,0.0001987998],"category_scores_gemma":[0.0001115031,0.0001963451,0.00005954671,0.0002714464,0.0009194993,0.0002046395,0.00007422093,0.000558413,0.000004678524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003941755,"about_ca_system_score_gemma":0.00004879547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000172867,"about_ca_topic_score_gemma":0.000001519371,"domain_scores_codex":[0.9980643,0.0002323891,0.0004734448,0.0006648041,0.0001970345,0.0003680128],"domain_scores_gemma":[0.9991861,0.0002460845,0.0001572626,0.0002367479,0.00003573634,0.0001380508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001062539,0.0005632627,0.007356286,0.00005629224,0.000002446415,0.00004478498,0.0002623979,0.000003354369,0.9808734,0.000002106637,0.000081199,0.01064819],"study_design_scores_gemma":[0.0009123775,0.00005455624,0.01096373,0.0000283237,0.0001054761,0.0001810691,0.00004956247,0.000009996599,0.9873918,0.000008129608,0.000102953,0.0001920314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973615,0.0003586039,5.139996e-7,0.001435638,0.0001859562,0.0004812596,0.00003965408,0.00004002714,0.00009680394],"genre_scores_gemma":[0.9985843,0.0004036118,0.00007344932,0.0004781841,0.00009059036,0.0001811165,0.000001891482,0.00001661249,0.0001702322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01045615,"threshold_uncertainty_score":0.8006721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896230610340603,"score_gpt":0.3234214971137737,"score_spread":0.2944591910103677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}