{"id":"W2120511656","doi":"10.2337/db10-0522","title":"β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Larry L. Hillblom Foundation","keywords":"Endoplasmic reticulum; Islet; Proteasome; Endoplasmic-reticulum-associated protein degradation; Ubiquitin; Amyloid (mycology); Downregulation and upregulation; Cell biology; Biology; Unfolded protein response; Apoptosis; Chemistry; Molecular biology; Endocrinology; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001997435,0.0002955582,0.0002672925,0.00008894796,0.0001041845,0.0000596697,0.0002868641,0.0002339985,0.0001067307],"category_scores_gemma":[0.0002490171,0.0002731686,0.0001094195,0.0002126831,0.000103349,0.00001253177,0.0001079851,0.0002635032,0.00009630515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002366919,"about_ca_system_score_gemma":0.0001154924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003818704,"about_ca_topic_score_gemma":0.00001103261,"domain_scores_codex":[0.9981645,0.00007382359,0.0003416041,0.0005589315,0.0002565917,0.0006045529],"domain_scores_gemma":[0.9990438,0.00006022695,0.0001288021,0.0004252646,0.0001137245,0.0002281918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002192971,0.0001629616,0.08187388,0.00009880787,0.00001691547,0.000002666926,0.00001233251,0.000006579318,0.9143096,0.00006707407,0.003209783,0.0002175142],"study_design_scores_gemma":[0.001091784,0.0002544846,0.009158668,0.000044149,0.00002912071,0.000001280827,0.00009973054,0.0003519071,0.9856321,0.00002516113,0.002852028,0.0004596438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944146,0.00205887,0.000003980119,0.00008062546,0.0006121981,0.0002823989,0.0001983933,0.00005197721,0.002296935],"genre_scores_gemma":[0.9981353,0.00004341382,0.00009169361,0.000271327,0.0002434485,0.0001022548,0.0008561096,0.00004275312,0.0002136806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07271521,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004299369419088602,"score_gpt":0.2012660708594541,"score_spread":0.1969667014403655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}