{"id":"W2120511656","doi":"10.2337/db10-0522","title":"β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Larry L. Hillblom Foundation","keywords":"Endoplasmic reticulum; Islet; Proteasome; Endoplasmic-reticulum-associated protein degradation; Ubiquitin; Amyloid (mycology); Downregulation and upregulation; Cell biology; Biology; Unfolded protein response; Apoptosis; Chemistry; Molecular biology; Endocrinology; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003124308,0.0006341499,0.0003139216,0.0003091416,0.0001427681,0.000339212,0.0001920177,0.0003016809,0.0008019127],"category_scores_gemma":[0.0001632297,0.0001827597,0.0002824485,0.0001674915,0.0003605792,0.0001957555,0.0002065603,0.0004717123,0.0001784369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002086261,"about_ca_system_score_gemma":0.0001463901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001598566,"about_ca_topic_score_gemma":0.0002303694,"domain_scores_codex":[0.9998595,0.00002700455,0.00002381228,0.00003594139,0.00002880666,0.00002487143],"domain_scores_gemma":[0.9998719,0.00001534037,0.00004897631,0.00001398292,0.000008042071,0.00004189494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000635043,0.0001152752,0.004072998,0.0001154677,0.00003251135,0.000937213,0.00003289838,0.0000881,0.9922748,0.00004683733,0.00004533629,0.001603424],"study_design_scores_gemma":[0.0004453088,0.001960791,0.1279951,0.00005704822,0.0002381457,0.01384643,0.0001759464,0.003006011,0.848878,0.0001890424,0.003183738,0.00002451581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976243,0.00111807,0.0008293638,0.00003139933,0.00001401709,0.00001542975,0.00006269487,0.00003519286,0.0002694351],"genre_scores_gemma":[0.9979911,0.0005904696,0.0008413112,0.00003923743,0.000009626353,0.00002542035,0.0001821553,0.000007676431,0.0003130565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008019127,"threshold_uncertainty_score":0.002682686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004299369419088602,"score_gpt":0.2012660708594541,"score_spread":0.1969667014403655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}