{"id":"W2120546271","doi":"10.1081/lpr-200033437","title":"Distal Cationic Poly(Ethylene Glycol) Lipid Conjugates in Large Unilamellar Vesicles Prepared by Extrusion Enhance Liposomal Cellular Uptake","year":2004,"lang":"en","type":"article","venue":"Journal of Liposome Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada); University of British Columbia","funders":"","keywords":"Liposome; Ethylene glycol; Extrusion; Vesicle; Cationic polymerization; Materials science; Lipid vesicle; Conjugate; PEG ratio; Cationic liposome; Chemical engineering; Chemistry; Polymer chemistry; Organic chemistry; Membrane; Nanotechnology; Biochemistry; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001259266,0.0001879947,0.0002843328,0.0002400694,0.000169477,0.00009081037,0.0005569972,0.0002348511,0.00005423636],"category_scores_gemma":[0.000247339,0.0001713028,0.0001505003,0.0003285697,0.0001598389,0.00003714291,0.000216581,0.000511587,0.000031674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001414052,"about_ca_system_score_gemma":0.0005382285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006951026,"about_ca_topic_score_gemma":0.0001494461,"domain_scores_codex":[0.9974949,0.0002440503,0.0006612574,0.0003456022,0.00065284,0.0006012929],"domain_scores_gemma":[0.9986109,0.00004620043,0.0002266998,0.0003691757,0.0005418142,0.0002052115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005250743,0.0004050785,0.001399076,0.00003367296,0.00005256123,0.00005699973,0.0002323442,0.00005422921,0.9951347,0.00005039792,0.0008353501,0.001220529],"study_design_scores_gemma":[0.001260277,0.001632329,0.00140395,0.0001681898,0.000009648871,0.00005290106,0.0003580063,0.00001886277,0.9822634,0.0002821455,0.01236942,0.0001808202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859358,0.01242362,0.0003949573,0.0006116253,0.0001847333,0.0001961962,0.00003257391,0.000004130211,0.0002163745],"genre_scores_gemma":[0.9946333,0.003768709,0.0001824786,0.00005756772,0.0005408702,0.000009745664,0.00005844414,0.00002867731,0.0007202685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01287124,"threshold_uncertainty_score":0.6985527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699946905856222,"score_gpt":0.3199714676081279,"score_spread":0.3029719985495657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}