{"id":"W2120570504","doi":"10.1200/jco.2011.41.4912","title":"Method to Our Madness or Madness in Our Methods? Pitfalls in Trial Methodology","year":2012,"lang":"en","type":"letter","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"Bristol-Myers Squibb","keywords":"Ipilimumab; Medicine; Carboplatin; Oncology; Clinical trial; Internal medicine; Chemotherapy; Regimen; Chemotherapy regimen; Immunotherapy; Cancer; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.657689,0.003384251,0.008173243,0.008888978,0.003521512,0.01815789,0.009285806,0.01299836,0.01070744],"category_scores_gemma":[0.8504171,0.002217831,0.004678233,0.007223693,0.02898984,0.0180198,0.00951803,0.03191083,0.004704906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007828745,"about_ca_system_score_gemma":0.02126373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003128427,"about_ca_topic_score_gemma":0.002422695,"domain_scores_codex":[0.2307053,0.6782484,0.04403321,0.01401157,0.03154346,0.001458066],"domain_scores_gemma":[0.08993808,0.8031872,0.01853955,0.04783508,0.03787645,0.002623631],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001721093,0.0001697502,0.002304173,0.01564284,0.003784261,0.0003312478,0.005959547,0.001189391,0.0003661464,0.2848956,0.3460406,0.3375953],"study_design_scores_gemma":[0.002326876,0.0004394734,0.0009929893,0.024145,0.001546372,0.0004709749,0.001148914,0.006847246,0.0006779194,0.5584474,0.4025232,0.0004336408],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0009304743,0.0567827,0.3335709,0.4601539,0.1349179,0.00404947,0.0008386876,0.001723184,0.007032825],"genre_scores_gemma":[0.03057355,0.01749042,0.4104606,0.425126,0.08545498,0.02458026,0.0003373412,0.001618144,0.00435865],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.342311,"threshold_uncertainty_score":0.4221304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5324042848346785,"score_gpt":0.6436033727356764,"score_spread":0.1111990879009979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}