{"id":"W2120599945","doi":"10.1093/molehr/gau001","title":"Oocyte-derived BMP15 but not GDF9 down-regulates connexin43 expression and decreases gap junction intercellular communication activity in immortalized human granulosa cells","year":2014,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Biology; Growth differentiation factor-9; Granulosa cell; Gene knockdown; Cell biology; Oocyte; Gap junction; Bone morphogenetic protein 15; Folliculogenesis; Cumulus oophorus; Connexin; Endocrinology; Cell culture; Internal medicine; Bone morphogenetic protein; Intracellular; Follicular phase; Bone morphogenetic protein 7; Genetics; Embryogenesis; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706465,0.0001822976,0.0003446292,0.0002192555,0.0001134171,0.000226416,0.0001178662,0.000164707,0.0007219118],"category_scores_gemma":[0.0001116078,0.0001209186,0.0003065215,0.000146205,0.0001814005,0.0001017717,0.0001627195,0.0003004728,0.000205953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885175,"about_ca_system_score_gemma":0.0002638489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001337163,"about_ca_topic_score_gemma":0.00153249,"domain_scores_codex":[0.9998667,0.00001843323,0.00002527162,0.00002149603,0.00003765909,0.00003033786],"domain_scores_gemma":[0.9999435,0.00001209426,0.00001384606,0.000008284063,0.000005802643,0.00001646171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001035871,0.00003186128,0.0002366852,0.00005327411,0.000006392432,0.0000749517,0.00002704684,0.00002477216,0.9984688,0.00006900641,0.00003754799,0.0008660586],"study_design_scores_gemma":[0.0000321368,0.0002612111,0.008613612,0.000008362023,0.00002366552,0.0002817057,0.00005814373,0.0003842408,0.9863635,0.00004188755,0.0039284,0.000003226532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995327,0.002189846,0.0009562836,0.00009510761,0.00003642697,0.00004316356,0.0003532877,0.00003111808,0.0009677197],"genre_scores_gemma":[0.9927706,0.002049548,0.002104371,0.0000969342,0.00001179888,0.00006835788,0.0008892897,0.00001715771,0.001991737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337163,"threshold_uncertainty_score":0.002658784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541648025829602,"score_gpt":0.2566678225530249,"score_spread":0.2412513422947289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}