{"id":"W2120599945","doi":"10.1093/molehr/gau001","title":"Oocyte-derived BMP15 but not GDF9 down-regulates connexin43 expression and decreases gap junction intercellular communication activity in immortalized human granulosa cells","year":2014,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Biology; Growth differentiation factor-9; Granulosa cell; Gene knockdown; Cell biology; Oocyte; Gap junction; Bone morphogenetic protein 15; Folliculogenesis; Cumulus oophorus; Connexin; Endocrinology; Cell culture; Internal medicine; Bone morphogenetic protein; Intracellular; Follicular phase; Bone morphogenetic protein 7; Genetics; Embryogenesis; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006925034,0.000314028,0.0003360321,0.0001636312,0.0003050891,0.00005860711,0.0002070077,0.0002985055,0.00003567429],"category_scores_gemma":[0.0001354632,0.0003209196,0.000125081,0.0001027539,0.0002759442,0.00001940438,0.0002372946,0.0002189057,0.00000517514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003888438,"about_ca_system_score_gemma":0.000018433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005596336,"about_ca_topic_score_gemma":0.0003196366,"domain_scores_codex":[0.997444,0.0006629455,0.0003988823,0.001046076,0.0001488334,0.0002992455],"domain_scores_gemma":[0.9982156,0.00001754604,0.0002516594,0.001301709,0.0001207863,0.00009271559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003727615,0.0001599641,0.0004932559,0.00003748169,0.00003287391,0.000003641999,0.00009858548,0.00005691995,0.9954646,0.0002217803,0.00006368671,0.002994451],"study_design_scores_gemma":[0.001330104,0.0003690262,0.01048127,0.00005187278,0.000040108,0.00002537528,0.00009538856,0.00009323034,0.9844289,0.0005357463,0.002188581,0.0003603784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966713,0.0005848481,0.001695551,0.000143421,0.0001615107,0.0004546182,0.000003759009,0.00005349629,0.0002314732],"genre_scores_gemma":[0.9985058,0.000136677,0.0002786258,0.00009685203,0.000182945,0.00006788784,0.0004496017,0.00004331209,0.0002382519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01103567,"threshold_uncertainty_score":0.9999243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541648025829602,"score_gpt":0.2566678225530249,"score_spread":0.2412513422947289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}