{"id":"W2120622571","doi":"10.1158/1541-7786.mcr-10-0457","title":"Notch1 Inhibition Alters the CD44hi/CD24lo Population and Reduces the Formation of Brain Metastases from Breast Cancer","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Robarts Research Institute; National Institutes of Health","keywords":"CD44; Medicine; Cancer research; Cancer; Phenotype; Breast cancer; Matrigel; Cancer stem cell; Metastasis; Population; Gene knockdown; Cancer cell; Cell; Pathology; Internal medicine; Biology; Cell culture; Angiogenesis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007606678,0.0001656333,0.000222215,0.0001960966,0.0001009118,0.0002633324,0.000129664,0.0001582929,0.001920224],"category_scores_gemma":[0.00006276159,0.00009452605,0.0001281434,0.00009966614,0.0001014711,0.0001241218,0.00009972689,0.0005658565,0.000363235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001738098,"about_ca_system_score_gemma":0.0001335264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006303045,"about_ca_topic_score_gemma":0.001088179,"domain_scores_codex":[0.9999213,0.00001020316,0.000005956262,0.00001219617,0.00002338864,0.00002693855],"domain_scores_gemma":[0.9999408,0.000006433149,0.0000115919,0.000004928897,0.000007037658,0.0000292864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001510349,0.00009427709,0.0002082676,0.0000194459,0.000004539582,0.00001958153,0.000009159528,0.00002421111,0.9975517,0.00002626749,0.00008206534,0.001809489],"study_design_scores_gemma":[0.00002047674,0.0009782586,0.01034105,0.000004748023,0.00001736339,0.0002025682,0.00005628405,0.0005806588,0.9858528,0.00003323984,0.001909247,0.000003189484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973931,0.000796528,0.0003874328,0.00007164889,0.00001509689,0.00001058753,0.0002359237,0.00004385552,0.001045735],"genre_scores_gemma":[0.9921119,0.0008472408,0.0006262155,0.00007940354,0.000007208572,0.00003665241,0.0005762042,0.00001727501,0.005697824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001920224,"threshold_uncertainty_score":0.006423771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0895629571686109,"score_gpt":0.3774363293595678,"score_spread":0.2878733721909569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}