{"id":"W2120624230","doi":"10.1093/nar/gku1311","title":"Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches","year":2014,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Université de Sherbrooke","keywords":"Biology; Oligonucleotide; RNA; Computational biology; Translation (biology); Untranslated region; G-quadruplex; Transcriptome; Gene; DNA; Nucleic acid structure; Messenger RNA; Gene expression; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001193383,0.0002951835,0.0002663643,0.0001361398,0.0003814485,0.0001285382,0.0007009726,0.00035584,0.0002326805],"category_scores_gemma":[0.0002497767,0.0002905518,0.0001954019,0.0003030336,0.0005340818,0.00001150116,0.0002368929,0.0004971321,0.0003139702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000312687,"about_ca_system_score_gemma":0.0001123187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001061719,"about_ca_topic_score_gemma":0.00001041031,"domain_scores_codex":[0.997138,0.0001924937,0.0003765131,0.000795429,0.000655848,0.0008416718],"domain_scores_gemma":[0.9983584,0.00009529925,0.00006696583,0.0008601135,0.0003086493,0.0003105678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001285026,0.0001193276,0.004163368,0.00004893686,0.0000493011,0.000009132536,0.00009617833,0.00003002006,0.9594012,0.0003611381,0.01023602,0.02535682],"study_design_scores_gemma":[0.0009135088,0.0002086516,0.006312506,0.00004158059,0.00000759006,0.00002475141,0.0002127878,0.0004178422,0.6306707,0.0005112712,0.360272,0.0004068119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9565237,0.0005024155,0.0006624692,0.0006135792,0.0001304126,0.000205198,0.00002762108,0.00005622473,0.04127836],"genre_scores_gemma":[0.9931731,0.0006717598,0.002407771,0.0002331518,0.001100322,0.00002176962,0.000194644,0.00008888531,0.002108553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.350036,"threshold_uncertainty_score":0.9999546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04318056087635549,"score_gpt":0.2959378674250601,"score_spread":0.2527573065487047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}