{"id":"W2120624230","doi":"10.1093/nar/gku1311","title":"Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches","year":2014,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Université de Sherbrooke","keywords":"Biology; Oligonucleotide; RNA; Computational biology; Translation (biology); Untranslated region; G-quadruplex; Transcriptome; Gene; DNA; Nucleic acid structure; Messenger RNA; Gene expression; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002379899,0.0003764225,0.0003263876,0.0002108764,0.0001165516,0.0002731317,0.0002025612,0.0003879496,0.001270917],"category_scores_gemma":[0.0002768721,0.0001449968,0.000209371,0.0001110625,0.0002134955,0.0001527743,0.0001429962,0.0004315256,0.0003143372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002197136,"about_ca_system_score_gemma":0.0001414379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001875006,"about_ca_topic_score_gemma":0.0004430934,"domain_scores_codex":[0.999832,0.00003635563,0.00001782006,0.00005440275,0.00003213462,0.00002711625],"domain_scores_gemma":[0.9998845,0.00004398666,0.00003007146,0.000009651674,0.00001339154,0.00001849593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008161317,0.00002389318,0.00003439037,0.00005841887,0.000004956577,0.00002306611,0.00001125169,0.00009640669,0.9963341,0.000357242,0.00008838248,0.002886318],"study_design_scores_gemma":[0.00005460804,0.0006842111,0.0002781006,0.000006404582,0.00002028713,0.00009404215,0.000009255128,0.0006072849,0.9924198,0.0001028905,0.005716977,0.000006134793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9480534,0.00788461,0.03337805,0.0005664946,0.0006302863,0.000439506,0.0008734521,0.0006963375,0.007477704],"genre_scores_gemma":[0.9696361,0.003999173,0.01984064,0.0004268494,0.0001181557,0.0003626047,0.0006452971,0.00006422619,0.004907011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270917,"threshold_uncertainty_score":0.004251659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04318056087635549,"score_gpt":0.2959378674250601,"score_spread":0.2527573065487047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}