{"id":"W2120639949","doi":"10.18433/j3ms40","title":"Effects of In Vivo Hepatic Ischemia-Reperfusion Injury on the Hepatobiliary Disposition of Rhodamine 123 and its Metabolites in Isolated Perfused Rat Livers","year":2012,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Texas Tech University","keywords":"Multidrug resistance-associated protein 2; Metabolite; Rhodamine 123; In vivo; Chemistry; Pharmacology; Pharmacokinetics; Ischemia; Excretion; Liver injury; Endocrinology; Internal medicine; Biochemistry; Transporter; Biology; ATP-binding cassette transporter; Medicine; Multiple drug resistance; Antibiotics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000467114,0.001002952,0.0006346506,0.0003056081,0.0001708728,0.0003572226,0.0002306621,0.0003142878,0.001884258],"category_scores_gemma":[0.0002037208,0.000267326,0.0006169663,0.0001774601,0.0007390798,0.0006151048,0.0002209301,0.0009190837,0.0003961949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003473441,"about_ca_system_score_gemma":0.000287938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004797491,"about_ca_topic_score_gemma":0.0005838689,"domain_scores_codex":[0.9998044,0.00003613968,0.00001597979,0.0000515795,0.00003184769,0.00006007232],"domain_scores_gemma":[0.999715,0.00003773782,0.0001169785,0.00004476035,0.00002134146,0.00006406405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003615825,0.0001564869,0.0004371986,0.00008084009,0.00002415133,0.0001121737,0.00004145273,0.00009745255,0.9931827,0.00005644559,0.0000390574,0.00215616],"study_design_scores_gemma":[0.00005996911,0.005012084,0.005048712,0.000006509216,0.00006808286,0.0001870336,0.00005621796,0.0005461258,0.9885323,0.00003189771,0.0004396756,0.00001139467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945471,0.002101379,0.00229555,0.00006744063,0.00005175273,0.0000355066,0.0001422717,0.0001194391,0.0006394984],"genre_scores_gemma":[0.9936181,0.001631231,0.002151378,0.00008021975,0.00004491239,0.00008305505,0.0004091444,0.00003621261,0.001945771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884258,"threshold_uncertainty_score":0.00630343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02406912304986594,"score_gpt":0.3328637692502186,"score_spread":0.3087946462003527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}