{"id":"W2120643517","doi":"10.1161/atvbaha.110.216143","title":"Enhanced Levels of Soluble CD40 Ligand Exacerbate Platelet Aggregation and Thrombus Formation Through a CD40-Dependent Tumor Necrosis Factor Receptor–Associated Factor-2/Rac1/p38 Mitogen-Activated Protein Kinase Signaling Pathway","year":2010,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Platelet activation; Platelet; Tumor necrosis factor alpha; Platelet factor 4; Cell biology; CD40; Chemistry; Protease-activated receptor; RAC1; Signal transduction; p38 mitogen-activated protein kinases; Kinase; Protein kinase A; Cancer research; Biology; Endocrinology; Immunology; Thrombin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002226186,0.0004926156,0.001090953,0.0001342659,0.0003262584,0.000081992,0.0001120999,0.0004340436,0.0001879367],"category_scores_gemma":[0.0001270606,0.0004098519,0.0002153673,0.0002401387,0.0002411336,0.0004897371,0.00009891095,0.0003292866,0.00001112976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000718267,"about_ca_system_score_gemma":0.00006900826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004212742,"about_ca_topic_score_gemma":0.0002174494,"domain_scores_codex":[0.997633,0.0001619776,0.0007085138,0.0006770291,0.0002598694,0.0005596229],"domain_scores_gemma":[0.9985826,0.0000888068,0.0005418322,0.0003804894,0.0002199281,0.0001863336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004477641,0.0003922788,0.007946139,0.0001160888,0.0006222344,6.98193e-7,0.002406485,5.793737e-7,0.9856721,0.00003580241,0.000009804379,0.002752969],"study_design_scores_gemma":[0.004408515,0.0008618299,0.1838872,0.0003129074,0.0001295305,0.000003216743,0.0002328275,0.0000672679,0.8095043,0.000125866,0.0001091798,0.0003573969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972953,0.0001201507,0.0003563073,0.00018012,0.0003001254,0.00130366,0.0003277072,0.00009399476,0.00002262903],"genre_scores_gemma":[0.9980474,0.0007240393,0.0006119802,0.0001262997,0.00003919444,0.0001071837,0.0002723387,0.00005522967,0.00001634681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1761678,"threshold_uncertainty_score":0.9998353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03663648196905778,"score_gpt":0.2703898669920334,"score_spread":0.2337533850229757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}