{"id":"W2120643517","doi":"10.1161/atvbaha.110.216143","title":"Enhanced Levels of Soluble CD40 Ligand Exacerbate Platelet Aggregation and Thrombus Formation Through a CD40-Dependent Tumor Necrosis Factor Receptor–Associated Factor-2/Rac1/p38 Mitogen-Activated Protein Kinase Signaling Pathway","year":2010,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Platelet activation; Platelet; Tumor necrosis factor alpha; Platelet factor 4; Cell biology; CD40; Chemistry; Protease-activated receptor; RAC1; Signal transduction; p38 mitogen-activated protein kinases; Kinase; Protein kinase A; Cancer research; Biology; Endocrinology; Immunology; Thrombin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001380902,0.0003577056,0.0002301044,0.000238162,0.0001083263,0.000260689,0.00008707997,0.0002860716,0.001575736],"category_scores_gemma":[0.0001125329,0.000097576,0.0001960204,0.00009589735,0.0001473236,0.0001481974,0.0001547074,0.0006601929,0.000276149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002227865,"about_ca_system_score_gemma":0.0001635016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001744903,"about_ca_topic_score_gemma":0.0002568582,"domain_scores_codex":[0.9997913,0.00004962303,0.00001733523,0.00002888728,0.00006542249,0.00004743339],"domain_scores_gemma":[0.9998766,0.00001146056,0.00004927667,0.000007700232,0.00001254747,0.0000424075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003169282,0.00008537192,0.0003644775,0.00004996083,0.000009498243,0.0001584701,0.00001493057,0.00004010662,0.997631,0.0001116561,0.00007982537,0.00113786],"study_design_scores_gemma":[0.0001463233,0.003090394,0.01441024,0.00002433673,0.00008246297,0.002155029,0.00005275094,0.002107603,0.9734072,0.0002086897,0.004306686,0.000008232574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957584,0.001598474,0.001303409,0.0001352687,0.00002944932,0.00003762426,0.0001463688,0.00005212632,0.0009389076],"genre_scores_gemma":[0.99628,0.0006319148,0.001216378,0.00008195784,0.00002679181,0.00003747107,0.000213035,0.000006283239,0.001506101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001575736,"threshold_uncertainty_score":0.005271375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03663648196905778,"score_gpt":0.2703898669920334,"score_spread":0.2337533850229757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}