{"id":"W2120647781","doi":"10.1128/jvi.01512-12","title":"The Asian-American E6 Variant Protein of Human Papillomavirus 16 Alone Is Sufficient To Promote Immortalization, Transformation, and Migration of Primary Human Foreskin Keratinocytes","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Nonmelanoma Skin Cancer Studies","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; Thunder Bay Regional Research Institute","funders":"","keywords":"Biology; Carcinogenesis; Telomerase reverse transcriptase; Telomerase; Oncogene; Cancer research; Foreskin; Cervical cancer; Malignant transformation; Population; Cancer; Transformation (genetics); Cell culture; Virology; Immunology; Genetics; Cell cycle; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002491449,0.0003075301,0.0002325635,0.000162455,0.000145378,0.0002489525,0.0001394102,0.0001891575,0.001030547],"category_scores_gemma":[0.0001997788,0.0001322972,0.000378361,0.0001579008,0.0001396553,0.000243934,0.0002450412,0.0003055091,0.0004953293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001321581,"about_ca_system_score_gemma":0.0001659301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006155813,"about_ca_topic_score_gemma":0.0007274259,"domain_scores_codex":[0.9997751,0.00004091517,0.00003152665,0.00003885474,0.00006035394,0.00005320155],"domain_scores_gemma":[0.9997603,0.00005854423,0.00003038762,0.00007515709,0.00003588296,0.00003974344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000900803,0.000034903,0.0003585321,0.00001725099,0.000006162638,0.00004250606,0.00002162164,0.00003330826,0.9984723,0.00004118501,0.0000180446,0.000864106],"study_design_scores_gemma":[0.000009325016,0.001246933,0.01519426,0.000007337601,0.00002540281,0.0009136627,0.000121841,0.0007234256,0.9784973,0.00004130518,0.003213003,0.000006177424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963689,0.0007064154,0.001603602,0.0000239657,0.00001920631,0.0000218851,0.0002261385,0.00002683813,0.001003099],"genre_scores_gemma":[0.9954284,0.0005565991,0.001536824,0.00001745227,0.000006250389,0.00001939985,0.0007711225,0.00001256328,0.001651326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030547,"threshold_uncertainty_score":0.003447473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01413029485650258,"score_gpt":0.2893589790795768,"score_spread":0.2752286842230742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}